{"doi":"10.1016/j.ymthe.2025.08.028","title":"Intratumoral delivery of 4-1BBL boosts IL-12-triggered anti-glioma immunity","abstract":"T cells are functionally suppressed in the tumor microenvironments (TME) of de novo and recurrent glioma patients, we tested whether anti-tumor response at the rIL-12-inflamed tumor site could be enhanced with 4-1BBL, the ligand of 4-1BB. 4-1BBL was delivered using an adeno-associated virus (AAV) vector targeting GFAP-expressing cells and resulted in prolonged survival of rIL-1 2-treated GB-bearing mice. This study establishes that tumor antigen (Ag)-specific CD8 T cell activity can be augmented by incorporating an AAV-vector-mediated gene therapy approach, effectively enhancing anti-GB immunity in the TME.","journal":"Molecular Therapy","year":2025,"id":524242,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9442,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":294638,"name":"Lisa Nieland","orcid":"0000-0002-4396-8252","position":1,"is_corresponding":false},{"id":1398305,"name":"Sanne M. van de Looij","orcid":null,"position":2,"is_corresponding":false},{"id":1258874,"name":"Alexandra J E M de Reus","orcid":null,"position":3,"is_corresponding":false},{"id":931959,"name":"Charles Couturier","orcid":"0000-0001-8015-7160","position":4,"is_corresponding":false},{"id":550731,"name":"Chadi A. El Farran","orcid":"0000-0002-9374-103X","position":5,"is_corresponding":false},{"id":88689,"name":"Tyler E. Miller","orcid":"0000-0002-1269-1895","position":6,"is_corresponding":false},{"id":1014809,"name":"Julia K. Lill","orcid":"0000-0001-8514-529X","position":7,"is_corresponding":false},{"id":1398306,"name":"Maryam Schübel","orcid":null,"position":8,"is_corresponding":false},{"id":1298398,"name":"Tianhe Xiao","orcid":null,"position":9,"is_corresponding":false},{"id":1397760,"name":"Emilio Di Ianni","orcid":"0000-0003-1789-2706","position":10,"is_corresponding":false},{"id":987575,"name":"Elliot C. Woods","orcid":"0000-0003-2920-8334","position":11,"is_corresponding":false},{"id":15989,"name":"Yi Sun","orcid":"0009-0003-1720-8844","position":12,"is_corresponding":false},{"id":1398307,"name":"David Rufino-Ramos","orcid":null,"position":13,"is_corresponding":false},{"id":731672,"name":"Thomas S. van Solinge","orcid":"0000-0003-3762-3618","position":14,"is_corresponding":false},{"id":732104,"name":"Shadi Mahjoum","orcid":null,"position":15,"is_corresponding":false},{"id":891220,"name":"Emily Grandell","orcid":null,"position":16,"is_corresponding":false},{"id":1397761,"name":"Li Mao","orcid":"0000-0002-1556-7793","position":17,"is_corresponding":false},{"id":2724,"name":"Vamsi Mangena","orcid":"0000-0003-2662-0366","position":18,"is_corresponding":false},{"id":231268,"name":"Gavin P. Dunn","orcid":"0000-0001-9302-4834","position":19,"is_corresponding":false},{"id":16006,"name":"Russell W. Jenkins","orcid":"0000-0001-6110-2148","position":20,"is_corresponding":false},{"id":616098,"name":"Thorsten R. Mempel","orcid":"0000-0001-8635-5424","position":21,"is_corresponding":false},{"id":166012,"name":"XANDRA O. BREAKEFIELD","orcid":null,"position":22,"is_corresponding":false},{"id":2732,"name":"Koen Breyne","orcid":"0000-0002-0713-2407","position":23,"is_corresponding":false},{"id":1015010,"name":"Taral R. Lunavat","orcid":"0000-0001-8198-1805","position":0,"is_corresponding":true}],"reference_count":114,"raw_metadata":null,"created_at":"2026-07-19T02:50:12.083054Z","pmid":"40842154","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}