{"doi":"10.1016/j.ymthe.2023.12.017","title":"Dexamethasone potentiates chimeric antigen receptor T cell persistence and function by enhancing IL-7Rα expression","abstract":"Dexamethasone (dex) is a glucocorticoid that is a mainstay for the treatment of inflammatory pathologies, including immunotherapy-associated toxicities, yet the specific impact of dex on the activity of CAR T cells is not fully understood. We assessed whether dex treatment given ex vivo or as an adjuvant in vivo with CAR T cells impacted the phenotype or function of CAR T cells. We demonstrated that CAR T cell expansion and function were not inhibited by dex. We confirmed this observation using multiple CAR constructs and tumor models, suggesting that this is a general phenomenon. Moreover, we determined that dex upregulated interleukin-7 receptor α on CAR T cells and increased the expression of genes involved in activation, migration, and persistence when supplemented ex vivo. Direct delivery of dex and IL-7 into tumor-bearing mice resulted in increased persistence of adoptively transferred CAR T cells and complete tumor regression. Overall, our studies provide insight into the use of dex to enhance CAR T cell therapy and represent potential novel strategies for augmenting CAR T cell function during production as well as following infusion into patients.","journal":"Molecular Therapy","year":2023,"id":337863,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":451900,"name":"Ryan Urak","orcid":"0000-0001-5289-5000","position":1,"is_corresponding":false},{"id":996586,"name":"Ellie Taus","orcid":"0000-0002-0872-3890","position":2,"is_corresponding":false},{"id":996587,"name":"Hui-Ju Hsieh","orcid":"0000-0002-2583-7670","position":3,"is_corresponding":false},{"id":996589,"name":"Dennis Awuah","orcid":"0000-0002-4295-5599","position":4,"is_corresponding":false},{"id":457032,"name":"Vibhuti Vyas","orcid":"0000-0001-6771-5666","position":5,"is_corresponding":false},{"id":451903,"name":"Laura Lim","orcid":"0009-0002-6848-7102","position":6,"is_corresponding":false},{"id":996588,"name":"Katherine Jin","orcid":"0000-0001-5824-601X","position":7,"is_corresponding":false},{"id":238235,"name":"Shu‐Hong Lin","orcid":"0000-0002-4020-7714","position":8,"is_corresponding":false},{"id":457033,"name":"Saul J. Priceman","orcid":"0000-0002-8136-2112","position":9,"is_corresponding":false},{"id":457036,"name":"Mary C. Clark","orcid":"0000-0003-1672-2684","position":10,"is_corresponding":false},{"id":625438,"name":"Lior Goldberg","orcid":"0000-0002-1643-7616","position":11,"is_corresponding":false},{"id":249979,"name":"Stephen J. Forman","orcid":"0000-0002-2803-4152","position":12,"is_corresponding":false},{"id":289779,"name":"Xiuli Wang","orcid":"0000-0001-5964-4327","position":13,"is_corresponding":false},{"id":996585,"name":"Ashlie Munoz","orcid":"0000-0001-8468-5438","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:10:31.133446Z","pmid":"38140726","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}