{"doi":"10.1016/j.yexmp.2020.104489","title":"MiR-487a-3p suppresses the malignant development of pancreatic cancer by targeting SMAD7","abstract":null,"journal":"Experimental and Molecular Pathology","year":2020,"id":634487,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1645600,"name":"Shuyan Qie","orcid":null,"position":1,"is_corresponding":false},{"id":1645602,"name":"Hongjuan Fang","orcid":null,"position":2,"is_corresponding":false},{"id":1645604,"name":"Jianing Xi","orcid":null,"position":3,"is_corresponding":false},{"id":1024213,"name":"Jing Zhou","orcid":"0000-0001-7935-5100","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"MiR-487a-3p suppresses the malignant development of pancreatic cancer by targeting SMAD7","abstract":"<h4>Objective</h4>To uncover the role of microRNA-487a-3p (miR-487a-3p) in influencing the malignant development of pancreatic cancer and the involvement of its downstream target SMAD7.<h4>Methods</h4>MiR-487a-3p level in 40 pancreatic cancer and paracancerous tissues was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The relationship between miR-487a-3p level and clinical indicators in pancreatic cancer patients was analyzed. Regulatory effects of miR-487a-3p on biological phenotypes of pancreatic cancer cells were assessed. At last, the involvement of miR-487a-3p and its downstream target SMAD7 in pancreatic cancer was determined.<h4>Results</h4>MiR-487a-3p was lowly expressed in pancreatic cancer tissues. Pancreatic cancer patients expressing a low level of miR-487a-3p suffered high metastasis rate and poor prognosis. Overexpression of miR-487a-3p markedly attenuated proliferative and migratory capacities in pancreatic cancer cells. SMAD7 was the downstream target of miR-487a-3p, which was highly expressed in pancreatic cancer samples. Overexpression of SMAD7 reversed the regulatory effects of miR-487a-3p on pancreatic cancer cell phenotypes.<h4>Conclusions</h4>MiR-487a-3p is downregulated in pancreatic cancer samples, which is linked to metastasis and prognosis in pancreatic cancer. It inhibits the malignant development of pancreatic cancer by negatively regulating SMAD7.","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32622014","pmcid":null,"openalex_id":"https://openalex.org/W3038917638","authors":[],"funders":[{"funder_name":"Natural Science Foundation of Beijing Municipality","grant_id":"7182049","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81500641","title":null}],"total_grants":2,"fwci":0.7457,"citation_percentile":0.67949536,"influential_citations":0,"citation_trend":[{"year":2021,"count":4},{"year":2022,"count":5},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0014480020307656?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014480020307656?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.yexmp.2020.104489","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32622014","host_type":"repository"}],"fields_of_study":["TGF-β signaling in diseases","MicroRNA in disease regulation","Chromatin Remodeling and Cancer","Aged","Carcinogenesis","Cell Line, Tumor","Cell Movement","Cell Proliferation","Female","Gene Expression Regulation, Neoplastic","Humans","Male","MicroRNAs","Middle Aged","Neoplasm Metastasis","Pancreatic Neoplasms","Prognosis","Smad7 Protein"],"mesh_terms":["Aged","Cell Movement","Female","Humans","Male","Middle Aged","Neoplasm Metastasis","Pancreatic Neoplasms","Prognosis","Gene Expression Regulation, Neoplastic","MicroRNAs","Cell Line, Tumor","Cell Proliferation","Smad7 Protein","Carcinogenesis"],"keywords":["Pancreatic cancer","Metastasis","microRNA","Cancer","Cancer research","CA19-9","Medicine","Internal medicine","Cancer cell","Phenotype","Oncology","Biology","Gene","Smad7","Mir-487a-3p","Malignant Development"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T13:45:04.340600Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}