{"doi":"10.1016/j.yexcr.2020.112448","title":"Knockdown of DDX46 suppresses the proliferation and invasion of gastric cancer through inactivating Akt/GSK-3β/β-catenin pathway","abstract":null,"journal":"Experimental Cell Research","year":2021,"id":608145,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1183195,"name":"Min Xu","orcid":"0000-0001-8245-4695","position":1,"is_corresponding":false},{"id":1561766,"name":"Wenting Zhong","orcid":null,"position":2,"is_corresponding":false},{"id":1561767,"name":"Yinghui Hu","orcid":null,"position":3,"is_corresponding":false},{"id":1273937,"name":"Guanghui Wang","orcid":"0009-0007-3341-8859","position":4,"is_corresponding":false},{"id":897104,"name":"Lihong Chen","orcid":"0000-0002-3742-1285","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Knockdown of DDX46 suppresses the proliferation and invasion of gastric cancer through inactivating Akt/GSK-3β/β-catenin pathway","abstract":"DEAD-box RNA helicase 46 (DDX46) has recently been identified as a candidate oncogene in several types of human malignancies. To date, the role of DDX46 in gastric cancer has not been determined. The purpose of the current study was to explore the role of DDX46 in gastric cancer and the potential mechanism. DDX46-silecing or overexpressing gastric cancer cell lines were established to validate the role of DDX46. Our results showed that the expression of DDX46 was significantly increased in gastric cancer tissues and cell lines. Knockdown of DDX46 suppressed the proliferation and invasion of gastric cancer cells. Whereas, DDX46 overexpression enhanced the cell proliferation and invasion of gastric cancer cells. Furthermore, knockdown of DDX46 markedly suppressed the tumor growth of xenografts. Research into the mechanism revealed that DDX46 depletion inhibited the Akt/GSK-3β/β-catenin signaling pathway in gastric cancer cells. Notably, activation of Akt or β-catenin overexpression reversed the DDX46 depletion-mediated anti-cancer effect. In conclusion, these findings indicated that DDX46 exerted an oncogenic role in gastric cancer via regulating the Akt/GSK-3β/β-catenin signaling pathway. Thus, DDX46 might be utilized as a therapeutic anti-cancer target.","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33347858","pmcid":null,"openalex_id":"https://openalex.org/W3113198240","authors":[],"funders":[{"funder_name":"Shaanxi Province","grant_id":"2020SF-258","title":null}],"total_grants":1,"fwci":0.5964,"citation_percentile":0.64644042,"influential_citations":0,"citation_trend":[{"year":2021,"count":3},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2024,"count":6},{"year":2025,"count":4}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0014482720307011?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014482720307011?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.yexcr.2020.112448","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33347858","host_type":"repository"}],"fields_of_study":["RNA Research and Splicing","Cancer-related molecular mechanisms research","RNA modifications and cancer","Adenocarcinoma","Animals","Cell Line, Tumor","Cell Movement","Cell Proliferation","DEAD-box RNA Helicases","Female","Gene Expression Regulation, Neoplastic","Gene Knockdown Techniques","Glycogen Synthase Kinase 3 beta","Humans","Mice","Mice, Nude","Neoplasm Invasiveness","Proto-Oncogene Proteins c-akt","RNA, Small Interfering","Ribonucleoprotein, U2 Small Nuclear","Signal Transduction","Stomach Neoplasms","beta Catenin"],"mesh_terms":["Glycogen Synthase Kinase 3 beta","Adenocarcinoma","Animals","Cell Movement","Female","Humans","Mice, Nude","Neoplasm Invasiveness","Stomach Neoplasms","Signal Transduction","Gene Expression Regulation, Neoplastic","Ribonucleoprotein, U2 Small Nuclear","RNA, Small Interfering","Cell Line, Tumor","Cell Proliferation","Proto-Oncogene Proteins c-akt","beta Catenin","Mice","DEAD-box RNA Helicases","Gene Knockdown Techniques"],"keywords":["Gene knockdown","Biology","Cancer","Protein kinase B","Oncogene","Cancer research","Catenin","Cancer cell","Cell growth","PI3K/AKT/mTOR pathway","Wnt signaling pathway","Signal transduction","Cell culture","Cell biology","Cell cycle","Biochemistry","Genetics","Cell proliferation","Gastric cancer","cell invasion","Ddx46","Akt/gsk-3β/β-catenin Signaling Pathway"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T07:34:51.589108Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}