{"doi":"10.1016/j.yexcr.2017.10.010","title":"Translation of noncoding RNAs: Focus on lncRNAs, pri-miRNAs, and circRNAs","abstract":null,"journal":"Experimental Cell Research","year":2017,"id":590583,"datarank":4.773864498996366,"base_score":4.820281565605037,"endowment":4.820281565605037,"self_citation_contribution":0.7230422348407557,"citation_network_contribution":4.0508222641556095,"self_endowment_contribution":0.7230422348407557,"citer_contribution":4.0508222641556095,"corpus_percentile":null,"corpus_rank":null,"citation_count":123,"citer_count":119,"citers_with_citation_signal":102,"citers_with_endowment":102,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1511050,"name":"Rui-Xue Leng","orcid":null,"position":1,"is_corresponding":false},{"id":1511051,"name":"Yin-Guang Fan","orcid":null,"position":2,"is_corresponding":false},{"id":1511052,"name":"Hai-Feng Pan","orcid":"0000-0001-6814-1553","position":3,"is_corresponding":false},{"id":1511053,"name":"Dong-Qing Ye","orcid":null,"position":4,"is_corresponding":false},{"id":1511049,"name":"Lian-Ju Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Translation of noncoding RNAs: Focus on lncRNAs, pri-miRNAs, and circRNAs","abstract":"Mammalian genome is pervasively transcribed, producing large number of noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs), primary miRNAs (pri-miRNA), and circular RNAs (circRNAs). The translation of these ncRNAs has long been overlooked. Increasing studies, however, based on ribosome profiling in various organisms provide important clues to unanticipated translation potential of lncRNAs. Moreover, a few functional peptides encoded by lncRNAs and pri-miRNAs underline the significance of their translation. Recently, several novel researches also evidence the translation of endogenous circRNAs. Given the functional significance exemplified by peptides translated by some ncRNAs and their pervasive translation, it is not too far-fetched to image that abnormal translation of ncRNAs may contribute to human diseases. Through challenging, deciphering ncRNA translation is required for comprehensive understanding of biology and medicine. In this review, we firstly present evidence concerning translation potential of lncRNAs and go on to introduce a few functional short peptides encoded by lncRNAs. Then, salient observations showing translation of pri-miRNAs and circRNAs are described in detail. We end by discussing the impact of ncRNA translation beyond producing peptides and referring briefly to the potential role of abnormal ncRNA translation in human diseases.","is_dataset_classified":null,"base_score":4.820281565605037,"endowment":4.820281565605037,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29031633","pmcid":null,"openalex_id":"https://openalex.org/W2764188251","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81673258","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81473058","title":null}],"total_grants":2,"fwci":4.4501,"citation_percentile":0.96309206,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2017,"count":3},{"year":2018,"count":11},{"year":2019,"count":10},{"year":2020,"count":32},{"year":2021,"count":20},{"year":2022,"count":9},{"year":2023,"count":14},{"year":2024,"count":13},{"year":2025,"count":7},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0014482717305414?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014482717305414?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.yexcr.2017.10.010","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29031633","host_type":"repository"}],"fields_of_study":["Cancer-related molecular mechanisms research","Circular RNAs in diseases","RNA modifications and cancer","Humans","MicroRNAs","Protein Biosynthesis","RNA","RNA, Circular","RNA, Long Noncoding"],"mesh_terms":["RNA, Circular","Humans","RNA","Protein Biosynthesis","MicroRNAs","RNA, Long Noncoding"],"keywords":["Biology","microRNA","Translation (biology)","Long non-coding RNA","Computational biology","Focus (optics)","Non-coding RNA","RNA","Genetics","Cell biology","Gene","Messenger RNA","Translation","miRNA","ncRNA","pri-miRNA","Lncrna","Circrna"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.26564625.v1","title":"Additional file 1 of Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26564625","title":"Additional file 1 of Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T02:42:41.855047Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}