{"doi":"10.1016/j.yexcr.2016.05.016","title":"β‐Taxilin participates in differentiation of C2C12 myoblasts into myotubes","abstract":null,"journal":"Experimental Cell Research","year":2016,"id":592339,"datarank":0.5573683928960149,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.17262598927678433,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.17262598927678433,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":10,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1515699,"name":"Tomohiko Makiyama","orcid":null,"position":1,"is_corresponding":false},{"id":1515700,"name":"Satoru Nogami","orcid":null,"position":2,"is_corresponding":false},{"id":1515701,"name":"Yukimi Horii","orcid":null,"position":3,"is_corresponding":false},{"id":1515702,"name":"Kenji Akasaki","orcid":null,"position":4,"is_corresponding":false},{"id":1515703,"name":"Hiromichi Shirataki","orcid":null,"position":5,"is_corresponding":false},{"id":1515698,"name":"Hiroshi Sakane","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"β‐Taxilin participates in differentiation of C2C12 myoblasts into myotubes","abstract":"Myogenesis is required for the development of skeletal muscle. Accumulating evidence indicates that the expression of several genes are upregulated during myogenesis and these genes play pivotal roles in myogenesis. However, the molecular mechanism underlying myogenesis is not fully understood. In this study, we found that β-taxilin, which is specifically expressed in the skeletal muscle and heart tissues, was progressively expressed during differentiation of C2C12 myoblasts into myotubes, prompting us to investigate the role of β-taxilin in myogenesis. In C2C12 cells, knockdown of β-taxilin impaired the fusion of myoblasts into myotubes, and decreased the diameter of myotubes. We also found that β-taxilin interacted with dysbindin, a coiled-coil-containing protein. Knockdown of dysbindin conversely promoted the fusion of myoblasts into myotubes and increased the diameter of myotubes in C2C12 cells. Furthermore, knockdown of dysbindin attenuated the inhibitory effect of β-taxilin depletion on myotube formation of C2C12 cells. These results demonstrate that β-taxilin participates in myogenesis through suppressing the function of dysbindin to inhibit the differentiation of C2C12 myoblasts into myotubes.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27231216","pmcid":null,"openalex_id":"https://openalex.org/W2404963149","authors":[],"funders":[],"total_grants":0,"fwci":0.1603,"citation_percentile":0.61693787,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2020,"count":1},{"year":2021,"count":3},{"year":2023,"count":3},{"year":2024,"count":1},{"year":2025,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0014482716301276?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0014482716301276?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.yexcr.2016.05.016","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27231216","host_type":"repository"}],"fields_of_study":["Muscle Physiology and Disorders","Cellular Mechanics and Interactions","Cardiomyopathy and Myosin Studies","Animals","COS Cells","Cell Differentiation","Chlorocebus aethiops","Dysbindin","Dystrophin-Associated Proteins","Gene Knockdown Techniques","Green Fluorescent Proteins","Humans","Immunoprecipitation","Mice","Muscle Fibers, Skeletal","Myoblasts","Nuclear Proteins","Protein Binding","Proto-Oncogene Proteins c-myc","Vesicular Transport Proteins"],"mesh_terms":["Dysbindin","Animals","Cell Differentiation","Chlorocebus aethiops","Humans","Nuclear Proteins","Protein Binding","Proto-Oncogene Proteins c-myc","Muscle Fibers, Skeletal","COS Cells","Myoblasts","Vesicular Transport Proteins","Immunoprecipitation","Dystrophin-Associated Proteins","Green Fluorescent Proteins","Mice","Gene Knockdown Techniques"],"keywords":["Myogenesis","C2C12","Myocyte","Biology","Gene knockdown","Skeletal muscle","Cell biology","Molecular biology","Gene","Anatomy","Genetics","Dysbindin","Taxilin"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T13:15:06.417843Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}