{"doi":"10.1016/j.ydbio.2025.12.013","title":"Drosophila as a model to study autophagy during oogenesis","abstract":null,"journal":"Developmental Biology","year":2026,"id":669868,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1749544,"name":"Nidhi Murmu","orcid":null,"position":1,"is_corresponding":false},{"id":1749545,"name":"Minal Ayachit","orcid":null,"position":2,"is_corresponding":false},{"id":1749546,"name":"Karan Selarka","orcid":null,"position":3,"is_corresponding":false},{"id":1749547,"name":"Kiran Nilangekar","orcid":null,"position":4,"is_corresponding":false},{"id":1749548,"name":"Bhupendra V. Shravage","orcid":"0000-0002-1329-8884","position":5,"is_corresponding":false},{"id":1749543,"name":"Mrunmayee Kulkarni","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Drosophila as a model to study autophagy during oogenesis","abstract":"Autophagy is an evolutionarily conserved catabolic process that is essential for maintaining cellular and developmental homeostasis in eukaryotes. Drosophila oogenesis offers a robust model for investigating the spatial and temporal regulation of autophagy within a complex developmental framework that involves cells from both germline and somatic lineages. This tightly regulated cascade of events enables the differentiation of a germline stem cell into a mature oocyte. Autophagy contributes to cellular quality control, nutrient sensing, and the regulation of developmental cell death, all of which are critical for proper egg development and maturation. Disruption of autophagy influences oogenesis, resulting in defective egg chamber development, altered apoptotic dynamics, abnormally shaped mitochondria and compromised mitophagy. Methodological advances, including immunofluorescence-based detection, live imaging using fluorescent reporters, and ultrastructural analysis via transmission electron microscopy, have significantly enhanced the ability to monitor autophagic activity in the ovary. This review summarizes current evidence that establishes autophagy as a key regulatory mechanism during oogenesis. Additionally, it offers an opportunity to investigate the role of autophagy in various cellular processes, including cell division, gene amplification, endocycling, collective cell migration, and cytoplasmic streaming for embryonic polarity, nurse cell dumping, and programmed cell death during Drosophila oogenesis.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41448329","pmcid":null,"openalex_id":"https://openalex.org/W7117126973","authors":[],"funders":[{"funder_name":"University Grants Commission","grant_id":"PGS/4204","title":null},{"funder_name":"University Grants Commission","grant_id":"175","title":null},{"funder_name":"University Grants Commission","grant_id":"196","title":null},{"funder_name":"University Grants Commission","grant_id":"ICMR-SRF 2020-6879/CMB-BMS","title":null},{"funder_name":"Council of Scientific and Industrial Research, India","grant_id":"216","title":null},{"funder_name":"Council of Scientific and Industrial Research, India","grant_id":"217","title":null},{"funder_name":"Council of Scientific and Industrial Research, India","grant_id":"18636","title":null},{"funder_name":"Council of Scientific and Industrial Research, India","grant_id":"11319","title":null},{"funder_name":"Council of Scientific and Industrial Research, India","grant_id":"09/0670","title":null},{"funder_name":"Council of Scientific and Industrial Research, India","grant_id":"09/670(0084)/2018-EMR-I","title":null},{"funder_name":"Council of Scientific and Industrial Research, India","grant_id":"PGS/3856","title":null},{"funder_name":"Council of Scientific and Industrial Research, India","grant_id":"165","title":null},{"funder_name":"Council for Scientific and Industrial Research","grant_id":"","title":null},{"funder_name":"Savitribai Phule Pune University","grant_id":"","title":null},{"funder_name":"Indian Council of Medical Research","grant_id":"","title":null}],"total_grants":15,"fwci":0.0,"citation_percentile":0.61936935,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0012160625003446?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0012160625003446?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ydbio.2025.12.013","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41448329","host_type":"repository"}],"fields_of_study":["Autophagy in Disease and Therapy","Hippo pathway signaling and YAP/TAZ","Microtubule and mitosis dynamics","Animals","Oogenesis","Autophagy","Female","Oocytes","Drosophila melanogaster","Drosophila","Apoptosis","Drosophila Proteins","Ovary"],"mesh_terms":["Animals","Autophagy","Drosophila","Drosophila melanogaster","Female","Oocytes","Oogenesis","Ovary","Apoptosis","Drosophila Proteins"],"keywords":["Autophagy","Germline","Programmed cell death","Somatic cell","Cytoplasm","Mitochondrion","Embryonic stem cell","microRNA","Cell","Aging","Drosophila","Oogenesis","Vitellogenesis","Starvation","Cell death","Nurse Cells","Mitophagy","Germline Stem Cells","Germarium"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-15T06:46:53.711522Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}