{"doi":"10.1016/j.ydbio.2012.09.006","title":"FGF signaling transforms non-neural ectoderm into neural crest","abstract":null,"journal":"Developmental Biology","year":2012,"id":682585,"datarank":0.5897738449086489,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"self_citation_contribution":0.5897738449086489,"citation_network_contribution":0.0,"self_endowment_contribution":0.5897738449086489,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":50,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1783216,"name":"Martín I García-Castro","orcid":null,"position":1,"is_corresponding":false},{"id":1783215,"name":"Nathan Yardley","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"FGF signaling transforms non-neural ectoderm into neural crest","abstract":"The neural crest arises at the border between the neural plate and the adjacent non-neural ectoderm. It has been suggested that both neural and non-neural ectoderm can contribute to the neural crest. Several studies have examined the molecular mechanisms that regulate neural crest induction in neuralized tissues or the neural plate border. Here, using the chick as a model system, we address the molecular mechanisms by which non-neural ectoderm generates neural crest. We report that in response to FGF the non-neural ectoderm can ectopically express several early neural crest markers (Pax7, Msx1, Dlx5, Sox9, FoxD3, Snail2, and Sox10). Importantly this response to FGF signaling can occur without inducing ectopic mesodermal tissues. Furthermore, the non-neural ectoderm responds to FGF by expressing the prospective neural marker Sox3, but it does not express definitive markers of neural or anterior neural (Sox2 and Otx2) tissues. These results suggest that the non-neural ectoderm can launch the neural crest program in the absence of mesoderm, without acquiring definitive neural character. Finally, we report that prior to the upregulation of these neural crest markers, the non-neural ectoderm upregulates both BMP and Wnt molecules in response to FGF. Our results provide the first effort to understand the molecular events leading to neural crest development via the non-neural ectoderm in amniotes and present a distinct response to FGF signaling.","is_dataset_classified":null,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23000357","pmcid":"PMC3541687","openalex_id":"https://openalex.org/W1965857163","authors":[],"funders":[{"funder_name":"Yale University Cell and Molecular Biology Training","grant_id":"GM007223","title":null},{"funder_name":"NIH","grant_id":"RO1DE017914","title":null},{"funder_name":"Medical Research Council","grant_id":"MR/K001744/1","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BBS/E/D/20310000","title":null},{"funder_name":"NIDCR NIH HHS","grant_id":"R01DE017914","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM007223","title":null},{"funder_name":"National Institutes of Health","grant_id":"5T32GM007223-17","title":"CELLULAR AND MOLECULAR BIOLOGY"}],"total_grants":7,"fwci":3.0853,"citation_percentile":0.90563013,"influential_citations":0,"citation_trend":[{"year":2013,"count":4},{"year":2014,"count":5},{"year":2015,"count":2},{"year":2016,"count":4},{"year":2017,"count":4},{"year":2018,"count":7},{"year":2019,"count":6},{"year":2020,"count":4},{"year":2021,"count":3},{"year":2022,"count":4},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S001216061200512X/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S001216061200512X/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S001216061200512X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S001216061200512X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ydbio.2012.09.006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23000357","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3541687","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.ydbio.2012.09.006","host_type":""},{"url":"https://dx.doi.org/10.1016/j.ydbio.2012.09.006","host_type":""}],"fields_of_study":["Congenital Anomalies and Fetal Surgery","Cleft Lip and Palate Research","Developmental Biology and Gene Regulation","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Bone Morphogenetic Proteins","Chick Embryo","Chickens","Ectoderm","Fibroblast Growth Factors","Gene Expression Regulation, Developmental","Neural Crest","PAX7 Transcription Factor","Signal Transduction"],"mesh_terms":["Animals","Chick Embryo","Chickens","Ectoderm","Fibroblast Growth Factors","Neural Crest","Signal Transduction","Gene Expression Regulation, Developmental","Bone Morphogenetic Proteins","PAX7 Transcription Factor"],"keywords":["Ectoderm","Neural fold","Neural plate","Neural crest","Biology","Neuroectoderm","Neural development","Neurulation","Mesoderm","Cell biology","Anatomy","Embryogenesis","Genetics","Embryo","Gastrulation","Embryonic stem cell","Gene Expression Regulation, Developmental","PAX7 Transcription Factor","Chick Embryo","Non-neural ectoderm","Pax7","Induction","Fibroblast Growth Factors","Bone Morphogenetic Proteins","FGF","Animals","Molecular Biology","Chickens","Developmental Biology","Signal Transduction"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"refseq"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T20:49:08.361953Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}