{"doi":"10.1016/j.ydbio.2012.06.010","title":"Analysis of transcriptional codes for zebrafish dopaminergic neurons reveals essential functions of Arx and Isl1 in prethalamic dopaminergic neuron development","abstract":null,"journal":"Developmental Biology","year":2012,"id":618768,"datarank":0.5775221402565088,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"self_citation_contribution":0.5775221402565088,"citation_network_contribution":0.0,"self_endowment_contribution":0.5775221402565088,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1596517,"name":"Chamaiphorn Jainok","orcid":null,"position":1,"is_corresponding":false},{"id":1596519,"name":"Wolfgang Driever","orcid":null,"position":2,"is_corresponding":false},{"id":1596515,"name":"Alida Filippi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Analysis of transcriptional codes for zebrafish dopaminergic neurons reveals essential functions of Arx and Isl1 in prethalamic dopaminergic neuron development","abstract":"Distinct groups of dopaminergic neurons develop at defined anatomical sites in the brain to modulate function of a large diversity of local and far-ranging circuits. However, the molecular identity as judged from transcription factor expression has not been determined for all dopaminergic groups. Here, we analyze regional expression of transcription factors in the larval zebrafish brain to determine co-expression with the Tyrosine hydroxylase marker in dopaminergic neurons. We define sets of transcription factors that clearly identify each dopaminergic group. These data confirm postulated relations to dopaminergic groups defined for mammalian systems. We focus our functional analysis on prethalamic dopaminergic neurons, which co-express the transcription factors Arx and Isl1. Morpholino-based knockdown reveals that both Arx and Isl1 are strictly required for prethalamic dopaminergic neuron development and appear to act in parallel. We further show that Arx contributes to patterning in the prethalamic region, while Isl1 is required for differentiation of prethalamic dopaminergic neurons.","is_dataset_classified":null,"base_score":3.8501476017100584,"endowment":3.8501476017100584,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22728160","pmcid":null,"openalex_id":"https://openalex.org/W2059208649","authors":[],"funders":[{"funder_name":"German Research Foundation","grant_id":"DFG-SFB780-B6","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"European Commission","grant_id":"223744","title":"Molecular Networks of Dopaminergic Neurons in Chordates"},{"funder_name":"government of Thailand","grant_id":"","title":null},{"funder_name":"European Commission (FP7, DOPAMINET, mdDANeurodev, ZFHEALTH)","grant_id":"","title":null}],"total_grants":5,"fwci":1.6789,"citation_percentile":0.81937382,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":4},{"year":2014,"count":6},{"year":2015,"count":2},{"year":2017,"count":2},{"year":2018,"count":4},{"year":2019,"count":2},{"year":2020,"count":7},{"year":2021,"count":4},{"year":2022,"count":5},{"year":2023,"count":6},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0012160612003193/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0012160612003193/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0012160612003193?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0012160612003193?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ydbio.2012.06.010","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22728160","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.ydbio.2012.06.010","host_type":""},{"url":"https://dx.doi.org/10.1016/j.ydbio.2012.06.010","host_type":""},{"url":"http://dx.doi.org/doi.org/10.1016/j.ydbio.2012.06.010","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.ydbio.2012.06.010","host_type":""}],"fields_of_study":["Zebrafish Biomedical Research Applications","Congenital heart defects research","Developmental Biology and Gene Regulation","0301 basic medicine","03 medical and health sciences","0303 health sciences","Animals","Body Patterning","Catecholamines","Dopaminergic Neurons","Embryo, Nonmammalian","Gene Expression Regulation, Developmental","Gene Knockdown Techniques","Hypothalamus","LIM-Homeodomain Proteins","Morpholinos","Preoptic Area","Rhombencephalon","Telencephalon","Thalamus","Transcription Factors","Transcription, Genetic","Zebrafish","Zebrafish Proteins"],"mesh_terms":["Animals","Catecholamines","Embryo, Nonmammalian","Hypothalamus","Preoptic Area","Rhombencephalon","Telencephalon","Thalamus","Transcription Factors","Transcription, Genetic","Zebrafish","Gene Expression Regulation, Developmental","Body Patterning","Zebrafish Proteins","Gene Knockdown Techniques","Dopaminergic Neurons","Morpholinos","LIM-Homeodomain Proteins"],"keywords":["Dopaminergic","Zebrafish","Biology","Gene knockdown","Transcription factor","Neuroscience","Tyrosine hydroxylase","Neuron","Dopamine","Cell biology","Gene","Genetics","Telencephalon","Embryo, Nonmammalian","Transcription, Genetic","LIM-Homeodomain Proteins","Hypothalamus","Morpholinos","Neuronal specification","Catecholamines","Thalamus","Transcription factors","Animals","Diencephalon","Molecular Biology","Body Patterning","Dopaminergic neuron","Dopaminergic Neurons","Gene Expression Regulation, Developmental","Zebrafish Proteins","Preoptic Area","Rhombencephalon","Gene Knockdown Techniques","Developmental Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T05:12:37.151629Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}