{"doi":"10.1016/j.ydbio.2010.03.022","title":"Robustness of positional specification by the Hedgehog morphogen gradient","abstract":null,"journal":"Developmental Biology","year":2010,"id":616162,"datarank":0.5050943744979712,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.0,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":281685,"name":"Alexandre Wojcinski","orcid":"0000-0002-5141-8568","position":1,"is_corresponding":false},{"id":1588452,"name":"Bruno Glise","orcid":null,"position":2,"is_corresponding":false},{"id":1588454,"name":"Nicholas A.M. Monk","orcid":null,"position":3,"is_corresponding":false},{"id":1588449,"name":"David J. Irons","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Robustness of positional specification by the Hedgehog morphogen gradient","abstract":"Spatial gradients of Hedgehog signalling play a central role in many patterning events during animal development, regulating cell fate determination and tissue growth in a variety of tissues and developmental stages. Experimental evidence suggests that many of the proteins responsible for regulating Hedgehog signalling and transport are themselves targets of Hedgehog signalling, leading to multiple levels of feedback within the system. We use mathematical modelling to analyse how these overlapping feedbacks combine to regulate patterning and potentially enhance robustness in the Drosophila wing imaginal disc. Our results predict that the regulation of Hedgehog transport and stability by glypicans, as well as multiple overlapping feedbacks in the Hedgehog response network, can combine to enhance the robustness of positional specification against variability in Hedgehog levels. We also discuss potential trade-offs between robustness and additional features of the Hedgehog gradient, such as signalling range and size regulation.","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20363217","pmcid":null,"openalex_id":"https://openalex.org/W1982087154","authors":[],"funders":[{"funder_name":"EPSRC","grant_id":"EP/D003105/1","title":"Amorphous computation, random graphs and complex biological networks"}],"total_grants":1,"fwci":1.2449,"citation_percentile":0.77125442,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2014,"count":1},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2019,"count":2},{"year":2021,"count":4},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":3},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S001216061000196X/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S001216061000196X/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S001216061000196X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S001216061000196X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ydbio.2010.03.022","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20363217","host_type":"repository"},{"url":"https://hal.science/hal-04688741","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.ydbio.2010.03.022","host_type":""},{"url":"https://dx.doi.org/10.1016/j.ydbio.2010.03.022","host_type":""}],"fields_of_study":["Hedgehog Signaling Pathway Studies","Developmental Biology and Gene Regulation","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Body Patterning","Drosophila Proteins","Drosophila melanogaster","Feedback","Gene Expression Regulation, Developmental","Hedgehog Proteins","Wings, Animal"],"mesh_terms":["Animals","Drosophila melanogaster","Feedback","Wings, Animal","Gene Expression Regulation, Developmental","Body Patterning","Drosophila Proteins","Hedgehog Proteins"],"keywords":["Morphogen","Hedgehog","Biology","Robustness (evolution)","Hedgehog signaling pathway","Signalling","Imaginal disc","Indian hedgehog","Cell biology","Computational biology","Neuroscience","Drosophila melanogaster","Evolutionary biology","Genetics","Signal transduction","Gene","HSPGs","Gene Expression Regulation, Developmental","Feedback","Animals","Drosophila Proteins","Wings, Animal","Hedgehog Proteins","Robustness","Molecular Biology","Drosophila wing imaginal disc","Developmental Biology","Body Patterning"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T22:09:57.585592Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}