{"doi":"10.1016/j.ydbio.2010.02.025","title":"CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans","abstract":null,"journal":"Developmental Biology","year":2010,"id":641964,"datarank":0.5533319181170905,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"self_citation_contribution":0.5533319181170905,"citation_network_contribution":0.0,"self_endowment_contribution":0.5533319181170905,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1669429,"name":"Varenka Rodriguez","orcid":null,"position":1,"is_corresponding":false},{"id":857163,"name":"Ismar Kovacevic","orcid":null,"position":2,"is_corresponding":false},{"id":1669430,"name":"Mouna Ibourk","orcid":null,"position":3,"is_corresponding":false},{"id":964857,"name":"Myeongwoo Lee","orcid":"0000-0003-2652-3646","position":4,"is_corresponding":false},{"id":292076,"name":"Erin J. Cram","orcid":"0000-0002-8129-1326","position":5,"is_corresponding":false},{"id":1669427,"name":"Hiba Tannoury","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans","abstract":"The two specialized C. elegans distal tip cells (DTCs) provide an in vivo model system for the study of developmentally regulated cell migration. We identified cacn-1/cactin, a well-conserved, novel regulator of cell migration in a genome-wide RNAi screen for regulators of DTC migration. RNAi depletion experiments and analysis of the hypomorphic allele cacn-1(tm3126) indicate that CACN-1 is required during DTC migration for proper pathfinding and for cessation of DTC migration at the end of larval morphogenesis. Strong expression of CACN-1 in the DTCs, and data from cell-specific RNAi depletion experiments, suggest that CACN-1 is required cell-autonomously to control DTC migration. Importantly, genetic interaction data with Rac GTPase activators and effectors suggest that CACN-1 acts specifically to inhibit the mig-2/Rac pathway, and in parallel to ced-10/Rac, to control DTC pathfinding.","is_dataset_classified":null,"base_score":3.6888794541139363,"endowment":3.6888794541139363,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20188721","pmcid":"PMC2854247","openalex_id":"https://openalex.org/W2084762099","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM085077","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM085077","title":null}],"total_grants":2,"fwci":0.9643,"citation_percentile":0.70977011,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":3},{"year":2014,"count":5},{"year":2015,"count":2},{"year":2016,"count":4},{"year":2017,"count":4},{"year":2018,"count":2},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.1016/j.ydbio.2010.02.025","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20188721","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2854247","host_type":"repository"}],"fields_of_study":["Genetics, Aging, and Longevity in Model Organisms","Muscle Physiology and Disorders","Reproductive Biology and Fertility"],"mesh_terms":["Animals","Carrier Proteins","Cell Movement","Gonads","Caenorhabditis elegans","rac GTP-Binding Proteins","Drosophila Proteins","Caenorhabditis elegans Proteins"],"keywords":["Biology","Caenorhabditis elegans","Cell biology","RNA interference","Cell migration","Genetic screen","GTPase","Effector","Regulator","Cell","Morphogenesis","Gene knockdown","Small GTPase","Genetics","Signal transduction","Phenotype","Gene","RNA"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T21:04:00.185231Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}