{"doi":"10.1016/j.ydbio.2008.02.061","title":"Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish","abstract":null,"journal":"Developmental Biology","year":2008,"id":590646,"datarank":3.1853434000136476,"base_score":4.465908118654584,"endowment":4.465908118654584,"self_citation_contribution":0.6698862177981877,"citation_network_contribution":2.5154571822154597,"self_endowment_contribution":0.6698862177981877,"citer_contribution":2.5154571822154597,"corpus_percentile":null,"corpus_rank":null,"citation_count":86,"citer_count":80,"citers_with_citation_signal":72,"citers_with_endowment":72,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1511223,"name":"Jean-Marie Delalande","orcid":null,"position":1,"is_corresponding":false},{"id":1511224,"name":"Ekaterina Kolmogorova","orcid":null,"position":2,"is_corresponding":false},{"id":1511225,"name":"Abigail Prier","orcid":null,"position":3,"is_corresponding":false},{"id":506126,"name":"Tu Nguyen","orcid":"0000-0003-0014-4349","position":4,"is_corresponding":false},{"id":1511226,"name":"Chelsey M. Smith","orcid":null,"position":5,"is_corresponding":false},{"id":1511227,"name":"Jochen Holzschuh","orcid":null,"position":6,"is_corresponding":false},{"id":1511228,"name":"Iain T. Shepherd","orcid":null,"position":7,"is_corresponding":false},{"id":1511222,"name":"Bettina Reichenbach","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish","abstract":"The zebrafish enteric nervous system (ENS), like those of all other vertebrate species, is principally derived from the vagal neural crest cells (NCC). The developmental controls that govern the migration, proliferation and patterning of the ENS precursors are not well understood. We have investigated the roles of endoderm and Sonic hedgehog (SHH) in the development of the ENS. We show that endoderm is required for the migration of ENS NCC from the vagal region to the anterior end of the intestine. We show that the expression of shh and its receptor ptc-1 correlate with the development of the ENS and demonstrate that hedgehog (HH) signaling is required in two phases, a pre-enteric and an enteric phase, for normal ENS development. We show that HH signaling regulates the proliferation of vagal NCC and ENS precursors in vivo. We also show the zebrafish hand2 is required for the normal development of the intestinal smooth muscle and the ENS. Furthermore we show that endoderm and HH signaling, but not hand2, regulate gdnf expression in the intestine, highlighting a central role of endoderm and SHH in patterning the intestine and the ENS.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18436202","pmcid":"PMC2435286","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK067285","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"DK067285","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01DK067285-03","title":"Development of the Zebrafish Enteric Nervous System"}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2435286","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0012160608001863?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0012160608001863?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ydbio.2008.02.061","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/18436202","host_type":""},{"url":"http://dx.doi.org/10.1016/j.ydbio.2008.02.061","host_type":""},{"url":"https://dx.doi.org/10.1016/j.ydbio.2008.02.061","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.ydbio.2008.02.061","host_type":""}],"fields_of_study":["0301 basic medicine","03 medical and health sciences","0303 health sciences"],"mesh_terms":["Enteric Nervous System","Stem Cells","Endoderm","Mesoderm","Animals","Animals, Genetically Modified","Zebrafish","Veratrum Alkaloids","Homeodomain Proteins","Zebrafish Proteins","Membrane Proteins","Receptors, Cell Surface","Nerve Tissue Proteins","High Mobility Group Proteins","Recombinant Fusion Proteins","Transcription Factors","In Situ Hybridization","Signal Transduction","Cell Movement","Gene Expression Regulation, Developmental","Body Patterning","Proto-Oncogene Proteins c-ret","Glial Cell Line-Derived Neurotrophic Factor","Hedgehog Proteins","SOX Transcription Factors","Patched Receptors","Patched-1 Receptor","Basic Helix-Loop-Helix Proteins"],"keywords":["Basic Helix-Loop-Helix Proteins","Patched Receptors","Hand2","Nerve Tissue Proteins","Receptors, Cell Surface","Enteric Nervous System","Animals, Genetically Modified","Mesoderm","Neural crest","Cell Movement","Animals","Cell migration","Hedgehog Proteins","Glial Cell Line-Derived Neurotrophic Factor","Molecular Biology","Zebrafish","In Situ Hybridization","Body Patterning","Homeodomain Proteins","Endoderm","Proto-Oncogene Proteins c-ret","High Mobility Group Proteins","Sonic hedgehog","Gene Expression Regulation, Developmental","Membrane Proteins","Cell Biology","GDNF","Patched-1 Receptor","Developmental Biology"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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