{"doi":"10.1016/j.ydbio.2007.04.044","title":"Foxi3 transcription factors and Notch signaling control the formation of skin ionocytes from epidermal precursors of the zebrafish embryo","abstract":null,"journal":"Developmental Biology","year":2007,"id":684368,"datarank":0.6995158641168101,"base_score":4.663439094112067,"endowment":4.663439094112067,"self_citation_contribution":0.6995158641168101,"citation_network_contribution":0.0,"self_endowment_contribution":0.6995158641168101,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":105,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":496277,"name":"Thomas J. Carney","orcid":"0000-0003-2371-1924","position":1,"is_corresponding":false},{"id":413664,"name":"Matthias Hammerschmidt","orcid":"0000-0002-3709-8166","position":2,"is_corresponding":false},{"id":94368,"name":"Martina Jänicke","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Foxi3 transcription factors and Notch signaling control the formation of skin ionocytes from epidermal precursors of the zebrafish embryo","abstract":"Ionocytes are specialized epithelial cell types involved in the maintenance of osmotic homeostasis. In amniotes, they are present in the renal system, while in water-living embryos of lower vertebrates additional ionocytes are found in the skin. Thus far, relatively little has been known about the mechanisms of ionocyte development. Here we demonstrate that skin ionocytes of zebrafish embryos derive from the same precursor cells as keratinocytes. Carrying out various combinations of gain- and loss-of-function studies, we show that the segregation of ionocytes from the epidermal epithelium is governed by an interplay between Notch signaling and two Forkhead-box transcription factors, Foxi3a and Foxi3b. The two foxi3 genes are expressed in ionocyte precursors and are required both for ionocyte-specific expression of the Notch ligand Jagged2a, and for ionocyte differentiation, characterized by the production of particular ATPases. Ionocytic Notch ligands, in turn, signal to neighboring cells, where activated Notch1 leads to a repression of foxi3 expression, allowing those cells to become keratinocytes. A model for ionocyte versus keratinocyte development will be presented, postulating additional thus far unidentified pro-ionocyte factors.","is_dataset_classified":null,"base_score":4.663439094112067,"endowment":4.663439094112067,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17555741","pmcid":null,"openalex_id":"https://openalex.org/W2089946206","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"1R01-GM63904","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM063904","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01GM063904-10","title":"Systematic Vertebrate Functional Genomics"},{"funder_name":"National Institutes of Health","grant_id":"5R01RR015402-02","title":"EXPRESSION OF THE ZEBRAFISH GENOME DURING EMBRYOGENESIS"}],"total_grants":4,"fwci":1.8876,"citation_percentile":0.85200569,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":6},{"year":2014,"count":9},{"year":2015,"count":7},{"year":2016,"count":5},{"year":2017,"count":2},{"year":2018,"count":3},{"year":2019,"count":10},{"year":2020,"count":4},{"year":2021,"count":9},{"year":2022,"count":5},{"year":2023,"count":6},{"year":2024,"count":6},{"year":2025,"count":3},{"year":2026,"count":3}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0012160607008676/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0012160607008676/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0012160607008676?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0012160607008676?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ydbio.2007.04.044","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17555741","host_type":"repository"},{"url":"http://hdl.handle.net/11858/00-001M-0000-002B-91C3-9","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.ydbio.2007.04.044","host_type":""},{"url":"https://dx.doi.org/10.1016/j.ydbio.2007.04.044","host_type":""},{"url":"https://hdl.handle.net/11858/00-001M-0000-002B-91C3-9","host_type":""}],"fields_of_study":["Developmental Biology and Gene Regulation","Epigenetics and DNA Methylation","Zebrafish Biomedical Research Applications","0301 basic medicine","03 medical and health sciences","0303 health sciences","Animals","Animals, Genetically Modified","Base Sequence","Calcium-Binding Proteins","Cell Differentiation","Cell Proliferation","DNA Primers","DNA, Antisense","Embryonic Stem Cells","Epistasis, Genetic","Forkhead Transcription Factors","In Situ Hybridization","Jagged-2 Protein","Keratinocytes","Ligands","Models, Biological","Receptors, Notch","Signal Transduction","Skin","Zebrafish","Zebrafish Proteins"],"mesh_terms":["Jagged-2 Protein","Animals","Base Sequence","Calcium-Binding Proteins","Cell Differentiation","Epistasis, Genetic","Ligands","Models, Biological","Skin","Zebrafish","Signal Transduction","Keratinocytes","DNA, Antisense","In Situ Hybridization","DNA Primers","Zebrafish Proteins","Animals, Genetically Modified","Cell Proliferation","Forkhead Transcription Factors","Receptors, Notch","Embryonic Stem Cells"],"keywords":["Notch signaling pathway","Zebrafish","Biology","Cell biology","Transcription factor","Psychological repression","Epidermis (zoology)","Keratinocyte","Homeostasis","Transcription (linguistics)","Embryo","Claudin","Signal transduction","Gene","Gene expression","Anatomy","Genetics","Cell culture","Tight junction","Ionocytes","Keratinocytes","Notch","Foxi3","Ligands","Models, Biological","DNA, Antisense","Animals, Genetically Modified","Osmoregulation","Animals","Molecular Biology","Embryonic Stem Cells","In Situ Hybridization","Cell Proliferation","DNA Primers","Skin","p63","Base Sequence","Receptors, Notch","Calcium-Binding Proteins","Cell Differentiation","Epistasis, Genetic","Forkhead Transcription Factors","Jagged-2 Protein","Developmental Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T13:55:30.547806Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}