{"doi":"10.1016/j.ydbio.2005.05.024","title":"MOM-5 Frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions","abstract":null,"journal":"Developmental Biology","year":2005,"id":680878,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1778962,"name":"Gregory C. Ellis","orcid":null,"position":1,"is_corresponding":false},{"id":378241,"name":"Bruce Bowerman","orcid":"0000-0002-6479-8707","position":2,"is_corresponding":false},{"id":1011408,"name":"Gian Garriga","orcid":"0000-0003-3641-9439","position":3,"is_corresponding":false},{"id":1778961,"name":"Nancy C. Hawkins","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"MOM-5 Frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions","abstract":"Asymmetric cell divisions produce all 302 neurons of the C. elegans hermaphrodite. Here, we describe a role for a C. elegans Dishevelled homolog, DSH-2, in an asymmetric neuroblast division. In dsh-2 mutants, neurons normally descended from the anterior neuroblast daughter of the ABpl/rpppa blast cell were frequently duplicated, while non-neuronal cells produced by the posterior daughter cell were often missing. These observations indicate that in the absence of dsh-2 function, the posterior daughter cell was transformed into a second anterior-like cell. Loss of mom-5, a C. elegans frizzled homolog, produced a similar phenotype. We also show that the DSH-2 protein localized to the cell cortex in most cells of the embryo. In the absence of MOM-5/Fz, DSH-2 was localized to the cytoplasm, suggesting that MOM-5 regulates asymmetric cell division by controlling the localization of DSH-2. Although all neurons in C. elegans are produced by an invariant pattern of cell divisions, our results indicate that cell signaling may contribute to asymmetric neuroblast division during embryogenesis.","is_dataset_classified":null,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15990090","pmcid":null,"openalex_id":"https://openalex.org/W2161811961","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"NS42213","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM49869","title":null}],"total_grants":2,"fwci":1.2017,"citation_percentile":0.75740741,"influential_citations":0,"citation_trend":[{"year":2013,"count":3},{"year":2014,"count":2},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2017,"count":3},{"year":2018,"count":2},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0012160605003374/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0012160605003374/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0012160605003374?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0012160605003374?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ydbio.2005.05.024","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15990090","host_type":"repository"}],"fields_of_study":["Genetics, Aging, and Longevity in Model Organisms","Selenium in Biological Systems","Animals","Animals, Genetically Modified","Caenorhabditis elegans","Caenorhabditis elegans Proteins","Cell Cycle Proteins","Cell Division","DNA Primers","Dishevelled Proteins","Gene Expression Regulation, Developmental","Membrane Proteins","Microscopy, Fluorescence","Nervous System","Neurons","RNA Interference","Signal Transduction"],"mesh_terms":["Dishevelled Proteins","Animals","Cell Division","Membrane Proteins","Microscopy, Fluorescence","Nervous System","Neurons","Signal Transduction","Caenorhabditis elegans","DNA Primers","Gene Expression Regulation, Developmental","Cell Cycle Proteins","Caenorhabditis elegans Proteins","Animals, Genetically Modified","RNA Interference"],"keywords":["Neuroblast","Frizzled","Biology","Asymmetric cell division","Cell division","Dishevelled","Caenorhabditis elegans","Cell biology","Cell polarity","Cell","Phenotype","Genetics","Neurogenesis","Signal transduction","Wnt signaling pathway","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T16:19:39.082231Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}