{"doi":"10.1016/j.xpro.2023.102391","title":"Isolation of primary human liver cells from normal and nonalcoholic steatohepatitis livers","abstract":"Here, we present a protocol for isolating human hepatocytes and neural progenitor cells from normal and nonalcoholic steatohepatitis livers. We describe steps for perfusion for scaled-up liver cell isolation and optimization of chemical digestion to achieve maximal yield and cell viability. We then detail a liver cell cryopreservation and potential applications, such as the use of human liver cells as a tool to link experimental and translational research.","journal":"STAR Protocols","year":2023,"id":339925,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.946,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":353975,"name":"Kevin Lam","orcid":"0000-0001-7073-0429","position":1,"is_corresponding":false},{"id":710792,"name":"Huayi Zhao","orcid":null,"position":2,"is_corresponding":false},{"id":1027810,"name":"Sadatsugu Sakane","orcid":"0000-0002-6306-4621","position":3,"is_corresponding":false},{"id":1027809,"name":"Hyun Young Kim","orcid":"0009-0006-2497-6229","position":4,"is_corresponding":false},{"id":1027811,"name":"Álvaro Eguileor","orcid":"0000-0002-0302-6762","position":5,"is_corresponding":false},{"id":1020647,"name":"Karin Diggle","orcid":null,"position":6,"is_corresponding":false},{"id":1028410,"name":"Shuai Wu","orcid":"0000-0002-9210-2033","position":7,"is_corresponding":false},{"id":1027812,"name":"Raquel Weber","orcid":"0000-0001-5083-9988","position":8,"is_corresponding":false},{"id":253288,"name":"Pejman Soroosh","orcid":null,"position":9,"is_corresponding":false},{"id":228442,"name":"Mojgan Hosseini","orcid":"0000-0002-6708-7126","position":10,"is_corresponding":false},{"id":714296,"name":"Kristin L. Mekeel","orcid":"0000-0002-8870-1287","position":11,"is_corresponding":false},{"id":232503,"name":"David A. Brenner","orcid":"0000-0003-2573-525X","position":12,"is_corresponding":false},{"id":226038,"name":"Tatiana Kisseleva","orcid":"0000-0001-9107-2306","position":13,"is_corresponding":false},{"id":233461,"name":"Xiao Liu","orcid":"0000-0002-1541-5546","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:10:49.535464Z","pmid":"37405925","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}