{"doi":"10.1016/j.xpro.2023.102132","title":"Targeted delivery of therapeutic agents to the mouse brain using a stereotactic-guided focused ultrasound device","abstract":"Existing protocols of focused ultrasound (FUS) combined with microbubble-mediated blood-brain barrier (BBB) opening (FUS-BBBO) in preclinical research require expensive ultrasound equipment and complex operating procedures. We developed a low-cost, easy-to-use, and precise FUS device for small animal models in preclinical research. Here, we provide a detailed protocol for building the FUS transducer, attaching the transducer to a stereotactic frame for precise brain targeting, applying the integrated FUS device to perform FUS-BBBO in mice, and evaluating the FUS-BBBO outcome. For complete details on the use and execution of this protocol, please refer to Hu et al. (2022).1","journal":"STAR Protocols","year":2023,"id":356122,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9608,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":342973,"name":"Yaoheng Yang","orcid":"0000-0001-8952-887X","position":1,"is_corresponding":false},{"id":425902,"name":"Dezhuang Ye","orcid":"0000-0001-9153-2990","position":2,"is_corresponding":false},{"id":1104886,"name":"Si Chen","orcid":"0000-0002-6785-4452","position":3,"is_corresponding":false},{"id":724308,"name":"Yan Gong","orcid":"0000-0003-0228-576X","position":4,"is_corresponding":false},{"id":575573,"name":"Chinwendu Chukwu","orcid":"0000-0001-9849-5328","position":5,"is_corresponding":false},{"id":342976,"name":"Hong Chen","orcid":"0000-0003-1904-0857","position":6,"is_corresponding":false},{"id":724307,"name":"Zhongtao Hu","orcid":"0000-0002-8359-6211","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-19T01:13:25.429924Z","pmid":"36861835","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}