{"doi":"10.1016/j.xpro.2022.101649","title":"Protocol for the isolation of CD8+ tumor-infiltrating lymphocytes from human tumors and their characterization by single-cell immune profiling and multiome","abstract":"TILs in tumors by single-cell RNA-seq paired to VDJ profiling and chromatin structure including dissociation of tumor biopsies. We have also provided guidance for subsequent fluorescence-activated cell sorting (FACS), single-cell encapsulation, bioinformatics analysis, and troubleshooting. For complete details on the use and execution of this protocol, please refer to Anadon et al. (2022).","journal":"STAR Protocols","year":2022,"id":285316,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.833,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":627233,"name":"Chaomei Zhang","orcid":null,"position":1,"is_corresponding":false},{"id":377318,"name":"Xuefeng Wang","orcid":"0000-0001-5775-408X","position":2,"is_corresponding":false},{"id":356130,"name":"Ling Cen","orcid":"0000-0003-4098-852X","position":3,"is_corresponding":false},{"id":242941,"name":"José R. Conejo-García","orcid":"0000-0001-6431-4074","position":4,"is_corresponding":false},{"id":356121,"name":"Xiaoqing Yu","orcid":"0000-0003-4585-9372","position":5,"is_corresponding":false},{"id":242935,"name":"Carmen M. Anadon","orcid":"0000-0002-8851-4545","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-19T00:29:40.826853Z","pmid":"36065294","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}