{"doi":"10.1016/j.xpro.2021.100463","title":"High-throughput generation of midbrain dopaminergic neuron organoids from reporter human pluripotent stem cells","abstract":"Here, we describe a high-throughput 3D differentiation protocol for deriving midbrain dopaminergic neurons from human pluripotent stem cells. The use of organoids has become prevalent in disease modeling, but there is a high demand for more homogeneous cultures. Our approach is advantageous for large-scale production of uniform midbrain organoids that can be maintained in diverse formats, and our reporters allow for sorting of dopaminergic neurons. The maturing long-term organoid cultures can be used as a model for the entire midbrain. For complete details on the use and execution of this protocol, please refer to Ahfeldt et al. (2020).","journal":"STAR Protocols","year":2021,"id":173363,"datarank":0.6875745800864117,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.2047432063561815,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.2047432063561815,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":16,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9445,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":344141,"name":"Gustavo Morrone Parfitt","orcid":"0000-0003-0168-4099","position":1,"is_corresponding":false},{"id":711072,"name":"Ricardo Reyes","orcid":"0000-0003-0371-2348","position":2,"is_corresponding":false},{"id":711073,"name":"Camille Goldman","orcid":"0000-0002-9089-7290","position":3,"is_corresponding":false},{"id":711074,"name":"Elena Coccia","orcid":"0000-0002-9849-2423","position":4,"is_corresponding":false},{"id":711075,"name":"Tatyana Kareva","orcid":"0000-0002-6625-0243","position":5,"is_corresponding":false},{"id":344135,"name":"Tim Ahfeldt","orcid":"0000-0001-6377-7376","position":6,"is_corresponding":false},{"id":344137,"name":"Lily Sarrafha","orcid":"0000-0002-6168-2119","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:46:49.903770Z","pmid":"33997803","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}