{"doi":"10.1016/j.xpro.2020.100223","title":"Two-parameter single-molecule analysis for measurement of chromatin mobility","abstract":"This protocol provides a two-parameter analysis of single-molecule tracking (SMT) trajectories of Halo-tagged histones in living adherent cell lines and unveils a chromatin mobility landscape composed of five chromatin types, ranging from low to high mobility. When the analysis is applied to Halo-tagged, chromatin-binding proteins, it associates chromatin interaction properties with known functions in a way that previously used SMT parameters did not. For complete information on the use and execution of this protocol, please refer to Lerner et al. (2020).","journal":"STAR Protocols","year":2020,"id":83848,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9151,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":267190,"name":"Pablo Aurelio Gómez-García","orcid":"0000-0002-4971-4229","position":1,"is_corresponding":false},{"id":267191,"name":"Ryan L. McCarthy","orcid":"0000-0003-4645-3526","position":2,"is_corresponding":false},{"id":430791,"name":"Zhe Liu","orcid":"0000-0002-3592-3150","position":3,"is_corresponding":false},{"id":267193,"name":"Melike Lakadamyali","orcid":"0000-0002-7524-6414","position":4,"is_corresponding":false},{"id":98970,"name":"Kenneth S. Zaret","orcid":"0000-0001-8932-3145","position":5,"is_corresponding":false},{"id":267189,"name":"Jonathan Lerner","orcid":"0000-0002-3513-3191","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-18T21:54:32.422022Z","pmid":"33377115","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}