{"doi":"10.1016/j.xphs.2021.01.015","title":"A Novel Experimental and Theoretical Method for Estimating Albumin-Mediated Hepatic Uptake Based on the Albumin Binding Fraction in Plasma and Human PK Prediction Using a Physiologically-Based Pharmacokinetic Approach","abstract":null,"journal":"Journal of Pharmaceutical Sciences","year":2021,"id":29986,"datarank":0.36274059761618044,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.12132491075106534,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.12132491075106534,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":163998,"name":"Tomoka Shimada","orcid":null,"position":1,"is_corresponding":false},{"id":163999,"name":"Kei Mayumi","orcid":null,"position":2,"is_corresponding":false},{"id":163996,"name":"Yu Egashira","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33476657","pmcid":null,"openalex_id":"https://openalex.org/W3122390182","authors":[],"funders":[],"total_grants":0,"fwci":0.271,"citation_percentile":0.56453077,"influential_citations":1,"citation_trend":[{"year":2021,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0022354921000307?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0022354921000307?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.xphs.2021.01.015","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33476657","host_type":"repository"}],"fields_of_study":["Drug Transport and Resistance Mechanisms","Protein Interaction Studies and Fluorescence Analysis","Pharmacogenetics and Drug Metabolism","Medicine","Chemistry","Albumins","Biological Transport","Humans","Liver","Models, Biological","Pharmaceutical Preparations","Pharmacokinetics"],"mesh_terms":["Albumins","Biological Transport","Pharmaceutical Preparations","Humans","Liver","Models, Biological","Pharmacokinetics"],"keywords":["Albumin","Physiologically based pharmacokinetic modelling","Pharmacokinetics","Chemistry","Plasma protein binding","Blood proteins","Free fraction","Serum albumin","Human serum albumin","Pharmacology","Chromatography","Biochemistry","Biology","Distribution","Physiologically based pharmacokinetics","Protein binding"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T01:33:37.514084Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}