{"doi":"10.1016/j.xops.2022.100257","title":"Acoustic Micro-Tapping Optical Coherence Elastography to Quantify Corneal Collagen Cross-Linking","abstract":"Purpose: To evaluate changes in the anisotropic elastic properties of ex vivo human cornea treated with ultraviolet cross-linking (CXL) using noncontact acoustic micro-tapping optical coherence elastography (AμT-OCE). Design: Acoustic micro-tapping OCE was performed on normal and CXL human donor cornea in an ex vivo laboratory study. Subjects: Normal human donor cornea (n = 22) divided into 4 subgroups. All samples were stored in optisol. Methods: , shear modulus) of normal and ultraviolet CXL-treated human corneas were quantified using noncontact AμT-OCE. A nearly incompressible transverse isotropic model was used to reconstruct moduli from AμT-OCE data. Independently, cornea elastic moduli were also measured with destructive mechanical tests (tensile extensometry and shear rheometry). Main Outcome Measures: , shear moduli) can be evaluated in both normal and CXL treated tissues, as well as monitored during the CXL procedure using noncontact AμT-OCE. Results: increased from 188 kPa to 673 kPa. Mechanical tests in a separate subgroup support CXL-induced cornea moduli changes and generally agree with noncontact AμT-OCE measurements. Conclusions: The human cornea is a highly anisotropic material where in-plane mechanical properties are very different from those out-of-plane. Noncontact AμT-OCE can measure changes in the anisotropic elastic properties in human cornea as a result of ultraviolet CXL.","journal":"Ophthalmology Science","year":2022,"id":245737,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8363,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":267788,"name":"Ivan Pelivanov","orcid":"0000-0003-4991-1481","position":1,"is_corresponding":false},{"id":880883,"name":"Gabriel Regnault","orcid":"0000-0002-7977-8549","position":2,"is_corresponding":false},{"id":451448,"name":"John J. Pitre","orcid":"0000-0002-0987-798X","position":3,"is_corresponding":false},{"id":880884,"name":"Ryan T. Wallace","orcid":"0000-0002-0206-2091","position":4,"is_corresponding":false},{"id":267789,"name":"Matthew O’Donnell","orcid":"0000-0001-8780-7613","position":5,"is_corresponding":false},{"id":284472,"name":"Ruikang K. Wang","orcid":"0000-0001-5169-8822","position":6,"is_corresponding":false},{"id":545620,"name":"Tueng T. Shen","orcid":"0000-0002-3351-8071","position":7,"is_corresponding":false},{"id":545619,"name":"Mitchell A. Kirby","orcid":"0000-0001-6042-8445","position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":null,"created_at":"2026-07-19T00:23:39.284121Z","pmid":"36685713","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}