{"doi":"10.1016/j.xkme.2019.11.007","title":"Uric Acid Lowering and Biomarkers of Kidney Damage in CKD Stage 3: A Post Hoc Analysis of a Randomized Clinical Trial","abstract":"RATIONALE & OBJECTIVE: Hyperuricemia is associated with chronic kidney disease (CKD) progression. We evaluated whether lowering serum uric acid levels improves levels of biomarkers of kidney damage. STUDY DESIGN: Post hoc analysis of clinical trial participants. SETTING & PARTICIPANTS: A double-blind randomized placebo-controlled study designed to lower serum uric acid levels. 80 patients with stage 3 CKD and asymptomatic hyperuricemia were randomly assigned to allopurinol treatment or placebo (300 mg/d) for 12 weeks. EXPOSURE/PREDICTOR: Allopurinol treatment versus placebo. OUTCOMES & MEASURES: We evaluated the change from baseline for the following urinary biomarkers of kidney damage: albumin-creatinine ratio (ACR), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule 1 (KIM-1), and transforming growth factor β1 (TGF-β1). Additionally, we evaluated CKD Epidemiology Collaboration (CKD-EPI)-estimated glomerular filtration rate (eGFR) and cystatin C eGFR. ANALYTICAL APPROACH: Generalized linear mixed modeling was used. RESULTS: < 0.001). Estimates for the change for allopurinol versus placebo over time were 1.09 (95% CI, 0.77-1.54) for ACR, 0.77 (95% CI, 0.36-1.63) for NGAL, and 2.36 (95% CI, 0.97-5.70) for TGF-β1. The model did not converge for KIM-1, but Wilcoxon signed rank test showed no significant difference in change from baseline between study groups. There was no significant change observed in CKD-EPI eGFR or cystatin C eGFR. LIMITATIONS: Post hoc analysis and short duration of the study. CONCLUSIONS: Uric acid-lowering with allopurinol is not associated with improvement in levels of biomarkers of kidney damage in patients with asymptomatic hyperuricemia and stage 3 CKD. FUNDING: The study was funded by the National Institutes of Health through a career development award, K23DK088833, and the Clinical and Translational Science Award UL1TR002537. TRIAL REGISTRATION: NCT01228903.","journal":"Kidney Medicine","year":2020,"id":70276,"datarank":0.8646174497142026,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.41525760868110395,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.41525760868110395,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":19,"citers_with_citation_signal":15,"citers_with_endowment":15,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7144,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01228903"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":372949,"name":"Nicholas T. Kruse","orcid":null,"position":1,"is_corresponding":false},{"id":371820,"name":"Emily Andrews","orcid":"0000-0003-2262-8600","position":2,"is_corresponding":false},{"id":372950,"name":"Zhiying You","orcid":null,"position":3,"is_corresponding":false},{"id":110793,"name":"Michel Chonchol","orcid":null,"position":4,"is_corresponding":false},{"id":274743,"name":"Chaorong Wu","orcid":"0000-0002-1569-0978","position":5,"is_corresponding":false},{"id":274745,"name":"Patrick Ten Eyck","orcid":"0000-0002-5041-0708","position":6,"is_corresponding":false},{"id":371821,"name":"Diana Zepeda‐Orozco","orcid":"0000-0003-0671-4453","position":7,"is_corresponding":false},{"id":232869,"name":"Diana Jalal","orcid":"0000-0002-1975-8650","position":8,"is_corresponding":false},{"id":372948,"name":"Loni Perrenoud","orcid":null,"position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-18T21:43:11.119231Z","pmid":"32964203","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}