{"doi":"10.1016/j.xjon.2025.10.039","title":"Uncontrolled hypertension contributes to vascular permeability after cardioplegic arrest and cardiopulmonary bypass","abstract":"Objective: Vasoplegia and endothelial dysfunction are well-known complications of cardioplegia and cardiopulmonary bypass (CP/CPB). Our lab has previously shown that endothelial adherens junction impairment is driven by vascular endothelial (VE)-cadherin phosphorylation. In this study we investigate the interplay of hypertension and CP/CPB. Methods: Right atrial tissue was harvested pre- and post-CP/CPB from patients undergoing surgery. Patients were stratified into nonhypertensive, controlled hypertension, and uncontrolled hypertension groups based on history and in-office blood pressure measurements. Atrial tissue was sent for transcriptomics. Expression, phosphorylation, and localization of VE-cadherin was assessed by immunoblotting and immunohistochemistry. Atrial microvascular reactivity to adenosine diphosphate was assessed by videomicroscopy. Results: < .05). Conclusions: Our study supports a 2-hit model in which hypertension primes the endothelium for dysfunction, and CP/CPB amplifies this injury through impaired reactive oxygen species handling, nitric oxide dysregulation, and adherens junction destabilization. These findings highlight the importance of preoperative hypertension management to improve postoperative outcomes.","journal":"JTCVS Open","year":2025,"id":583747,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9594,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1215026,"name":"Christopher R. Stone","orcid":null,"position":1,"is_corresponding":false},{"id":1436604,"name":"Rishik Manthana","orcid":null,"position":2,"is_corresponding":false},{"id":1496715,"name":"Himanshu Kaushik","orcid":null,"position":3,"is_corresponding":false},{"id":1437981,"name":"Kelsey Muir","orcid":"0000-0001-8768-5468","position":4,"is_corresponding":false},{"id":1222955,"name":"Jad Hamze","orcid":"0009-0000-2758-8746","position":5,"is_corresponding":false},{"id":381665,"name":"Afshin Ehsan","orcid":"0000-0003-1470-6760","position":6,"is_corresponding":false},{"id":373708,"name":"Neel R. Sodha","orcid":"0000-0001-9720-9895","position":7,"is_corresponding":false},{"id":404964,"name":"Jun Feng","orcid":"0000-0003-4762-7532","position":8,"is_corresponding":false},{"id":371889,"name":"Frank W. Sellke","orcid":"0000-0002-8886-801X","position":9,"is_corresponding":false},{"id":1222953,"name":"Meghamsh Kanuparthy","orcid":"0009-0005-7581-0555","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:59:07.970345Z","pmid":"41960100","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}