{"doi":"10.1016/j.xjon.2025.04.016","title":"Venovenous extracorporeal membrane oxygenation with mechanical chest compression for cardiopulmonary resuscitation: A porcine model study","abstract":"Objective: To evaluate the effectiveness of venovenous (VV) extracorporeal membrane oxygenation (ECMO) using a dual-lumen cannula coupled with continuous mechanical chest compressions (cMCC) for cardiopulmonary resuscitation and compare it with venoarterial (VA) ECMO or cMCC only, in a preclinical model. Methods: Twenty-three pigs were allocated into 3 experimental groups: cMCC using a LUCAS 3 compression device, VA-ECMO, and cMCC + VV-ECMO. After cannulation, ventricular fibrillation was induced and circulatory support initiated per allocation. Defibrillation occurred after 30 minutes of support initiation. Hemodynamic, echocardiographic, and laboratory measurements were collected at different timepoints. The primary outcome was the rate of return of spontaneous circulation (ROSC). Results: = .06). Conclusions: cMCC in association with VV-ECMO using a single dual-lumen femoral cannula may be a viable option of extracorporeal cardiopulmonary resuscitation, potentially leading to greater rates of ROSC when compared with cMCC alone. Additional studies are needed to determine whether this strategy could serve as an early alternative to VA-ECMO in the out-of-hospital cardiac arrest setting.","journal":"JTCVS Open","year":2025,"id":565253,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1425919,"name":"Paulo Cézar Gregório","orcid":"0000-0002-8954-2855","position":1,"is_corresponding":false},{"id":919324,"name":"Shampa Chatterjee","orcid":"0000-0002-1365-5167","position":2,"is_corresponding":false},{"id":908203,"name":"Asad Usman","orcid":"0000-0002-3874-9741","position":3,"is_corresponding":false},{"id":1469005,"name":"Gerald Broniec","orcid":null,"position":4,"is_corresponding":false},{"id":1212362,"name":"Andrés Bermúdez","orcid":"0009-0002-7201-8245","position":5,"is_corresponding":false},{"id":204993,"name":"Thomas Richards","orcid":"0000-0001-5945-6545","position":6,"is_corresponding":false},{"id":1469006,"name":"Jonathan Salas","orcid":null,"position":7,"is_corresponding":false},{"id":1469007,"name":"Kathryn S. Gray","orcid":null,"position":8,"is_corresponding":false},{"id":329904,"name":"Cory M. Tschabrunn","orcid":"0000-0003-2887-1150","position":9,"is_corresponding":false},{"id":609043,"name":"Christian Bermudez","orcid":"0009-0002-1252-5528","position":10,"is_corresponding":false},{"id":1468743,"name":"F. Sertic","orcid":"0000-0002-2221-8639","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-19T02:56:28.709936Z","pmid":"40631007","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}