{"doi":"10.1016/j.xjon.2024.11.020","title":"Association of dysautonomia with refractory ventricular tachyarrhythmia in patients requiring thoracoscopic surgical cardiac sympathetic denervation","abstract":"Objective: Although cardiac sympathetic denervation (CSD) effectively manages refractory ventricular tachyarrhythmias (RVTs) in long-QT syndrome and catecholaminergic polymorphic ventricular tachycardia, the link between dysautonomia and RVT from broader etiologies is understudied. We hypothesized that dysautonomia is linked to RVT regardless of etiology in patients requiring CSD. We aimed to determine whether these patients have a high burden of dysautonomia symptoms using the Composite Autonomic Symptom Score-31 (COMPASS-31). Methods: tests. Comparisons were made between patients with and without structural heart disease, and multivariable regression identified predictors for COMPASS-31 scores and CSD response. Results: < .001). No differences were found between patients with and without structural heart disease, and no predictors for COMPASS-31 score were identified. One year post-CSD, 78.4% of patients remained free of implantable cardioverter-defibrillator shocks. Conclusions: Dysautonomia symptoms are significantly associated with RVT requiring CSD, regardless of underlying etiology. This association, in the context of CSD efficacy in RVT across structural and nonstructural etiologies, highlights autonomic dysfunction as a common pathophysiologic link warranting further investigation.","journal":"JTCVS Open","year":2024,"id":482608,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9592,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":552092,"name":"Dianela Perdomo","orcid":"0000-0001-5502-5238","position":1,"is_corresponding":false},{"id":1323124,"name":"Hamza Khan","orcid":"0000-0002-6553-5343","position":2,"is_corresponding":false},{"id":1323550,"name":"Kelsey Melinosky","orcid":null,"position":3,"is_corresponding":false},{"id":474858,"name":"Anna Chudnovets","orcid":"0000-0002-5406-8882","position":4,"is_corresponding":false},{"id":1323125,"name":"Jacob Blum","orcid":"0000-0003-0140-5555","position":5,"is_corresponding":false},{"id":1323551,"name":"Mahmoud Kutmah","orcid":null,"position":6,"is_corresponding":false},{"id":980649,"name":"Victor X. D. Yang","orcid":"0000-0002-1166-8271","position":7,"is_corresponding":false},{"id":1323126,"name":"Albert Leng","orcid":"0000-0001-8049-7624","position":8,"is_corresponding":false},{"id":336298,"name":"Arjun K. Menta","orcid":"0000-0002-6371-6052","position":9,"is_corresponding":false},{"id":1323552,"name":"Xiyu Zhao","orcid":null,"position":10,"is_corresponding":false},{"id":1099657,"name":"Suguru Yamauchi","orcid":"0000-0001-5418-7112","position":11,"is_corresponding":false},{"id":741835,"name":"Kristen Rodgers","orcid":"0000-0003-4302-9578","position":12,"is_corresponding":false},{"id":1323553,"name":"Kathryn Ecoff","orcid":null,"position":13,"is_corresponding":false},{"id":254628,"name":"Errol L. Bush","orcid":"0000-0003-1251-8467","position":14,"is_corresponding":false},{"id":749439,"name":"Andreas S. Barth","orcid":"0000-0001-5275-8049","position":15,"is_corresponding":false},{"id":14335,"name":"Malcolm V. Brock","orcid":null,"position":16,"is_corresponding":false},{"id":747000,"name":"Frank Bosmans","orcid":"0000-0002-0451-6050","position":17,"is_corresponding":false},{"id":1323127,"name":"Jinny S Ha","orcid":"0000-0003-1044-8186","position":18,"is_corresponding":false},{"id":1099656,"name":"Andrei Gurau","orcid":"0000-0003-4610-721X","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:07:18.280369Z","pmid":"40061532","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}