{"doi":"10.1016/j.xjon.2024.08.005","title":"Out of the ice age: Preservation of cardiac allografts with a reusable 10 °C cooler","abstract":"Objective: Static cold storage with ice has been the mainstay of cardiac donor preservation. Early preclinical data suggest that allograft preservation at 10 °C may be beneficial. We tested this hypothesis by using a static 10 °C storage device to preserve and transport cardiac allografts. Methods: In total, 52 allografts were recovered between July 2023 and March 2024 and transported using a 10 °C storage cooler. Results were compared to a 3:1 propensity match of allografts transported on ice. Patients were excluded for the following reasons: dual viscera transplant, previous heart transplant, complex congenital heart disease, or allograft injury during procurement. Results: > .99). 10 °C hearts demonstrated less change in lactate but no difference in vasoactive inotrope scores or cardiac index. In hearts with extended ischemic time, delta lactate was lower in 10 °C cooler hearts. There was no statistical difference in outcomes for donor hearts >40 years old. Conclusions: This is an early experience of static preservation in a 10 °C cooler. Postoperative allograft function was excellent, and lactate profiles lower in those allografts with extended ischemic times. Static cold storage targeting 10 °C may offer an inexpensive method for extended heart preservation. Further investigation is needed to assess long-term outcomes of 10 °C storage.","journal":"JTCVS Open","year":2024,"id":424302,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9194,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1120062,"name":"Timothy Harris","orcid":"0000-0002-3939-6263","position":1,"is_corresponding":false},{"id":1141393,"name":"Mark Petrovic","orcid":"0000-0003-3922-3431","position":2,"is_corresponding":false},{"id":1221239,"name":"Anthony Dreher","orcid":null,"position":3,"is_corresponding":false},{"id":1099419,"name":"Chetan Pasrija","orcid":"0000-0003-4487-4343","position":4,"is_corresponding":false},{"id":1221240,"name":"Stephen A DeVries","orcid":null,"position":5,"is_corresponding":false},{"id":1221241,"name":"Swaroop Bommareddi","orcid":null,"position":6,"is_corresponding":false},{"id":334561,"name":"Brian Lima","orcid":"0000-0002-2555-2229","position":7,"is_corresponding":false},{"id":1220680,"name":"Chen Chia Wang","orcid":"0009-0001-9491-7586","position":8,"is_corresponding":false},{"id":948762,"name":"Michael Cortelli","orcid":null,"position":9,"is_corresponding":false},{"id":1220681,"name":"Avery Fortier","orcid":"0009-0008-1473-4132","position":10,"is_corresponding":false},{"id":1221242,"name":"Kaitlyn Tracy","orcid":null,"position":11,"is_corresponding":false},{"id":948248,"name":"Elizabeth Simonds","orcid":"0000-0002-3124-1769","position":12,"is_corresponding":false},{"id":1221243,"name":"Clifton D Keck","orcid":null,"position":13,"is_corresponding":false},{"id":1221244,"name":"Shelley R Scholl","orcid":null,"position":14,"is_corresponding":false},{"id":376631,"name":"Hasan K. Siddiqi","orcid":"0000-0002-2274-9405","position":15,"is_corresponding":false},{"id":623386,"name":"Kelly Schlendorf","orcid":"0000-0002-8811-1957","position":16,"is_corresponding":false},{"id":560727,"name":"Matthew Bacchetta","orcid":"0000-0003-4456-4484","position":17,"is_corresponding":false},{"id":1140633,"name":"Ashish S. Shah","orcid":"0000-0002-3375-7865","position":18,"is_corresponding":false},{"id":1099418,"name":"John M. Trahanas","orcid":"0000-0001-8644-5489","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:58:07.191194Z","pmid":"39534335","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}