{"doi":"10.1016/j.xjon.2024.06.003","title":"Intramyocardial injection of hypoxia-conditioned extracellular vesicles increases myocardial perfusion in a swine model of chronic coronary disease","abstract":"Objective: Coronary artery disease remains a leading cause of morbidity and mortality worldwide. Patients with advanced coronary artery disease who are not eligible for endovascular or surgical revascularization have limited options. Extracellular vesicles have shown potential to improve myocardial function in preclinical models. Extracellular vesicles can be conditioned to modify their components. Hypoxia-conditioned extracellular vesicles have demonstrated the ability to reduce infarct size and apoptosis in small animals. Our objective is to assess the potential benefits of hypoxia-conditioned extracellular vesicles in a large animal model of coronary artery disease. Methods: Coronary artery disease was induced in 14 Yorkshire swine by ameroid constriction of the left circumflex coronary artery. Two weeks postsurgery, swine underwent a repeat left thoracotomy for injections of hypoxia-conditioned extracellular vesicles (n = 7) or saline (control, n = 7). Five weeks later, all animals underwent terminal harvest for perfusion measurements and myocardial sectioning. Results: = .01) in the hypoxia-conditioned extracellular vesicles group. Conclusions: Intramyocardial injection of hypoxia-conditioned extracellular vesicles results in increased myocardial perfusion without a corresponding change in vessel density. Therefore, this improvement in perfusion is possibly due to changes in nitric oxide signaling. Hypoxia-conditioned extracellular vesicles represent a potential therapeutic strategy to increase myocardial perfusion in patients with advanced coronary artery disease.","journal":"JTCVS Open","year":2024,"id":498506,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9534,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":937832,"name":"Sharif A. Sabe","orcid":"0000-0002-8169-6753","position":1,"is_corresponding":false},{"id":1068729,"name":"Mark Broadwin","orcid":"0000-0002-0393-9983","position":2,"is_corresponding":false},{"id":1275146,"name":"Christopher Stone","orcid":"0000-0002-9621-5334","position":3,"is_corresponding":false},{"id":345079,"name":"Cynthia Xu","orcid":"0000-0002-2191-3066","position":4,"is_corresponding":false},{"id":1222953,"name":"Meghamsh Kanuparthy","orcid":"0009-0005-7581-0555","position":5,"is_corresponding":false},{"id":1068728,"name":"Akshay Malhotra","orcid":"0000-0001-5047-6320","position":6,"is_corresponding":false},{"id":373709,"name":"M. Ruhul Abid","orcid":"0000-0003-2981-2638","position":7,"is_corresponding":false},{"id":371889,"name":"Frank W. Sellke","orcid":"0000-0002-8886-801X","position":8,"is_corresponding":false},{"id":930600,"name":"Dwight D. Harris","orcid":"0000-0001-8289-2740","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:09:42.181447Z","pmid":"39296447","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}