{"doi":"10.1016/j.xjon.2021.02.003","title":"Influence of administration of mesenchymal stromal cell on pediatric oxygenator performance and inflammatory response","abstract":"OBJECTIVE: Mesenchymal stromal cells have important immunomodulatory and neuroprotective properties. The aim of this study was to evaluate the feasibility of mesenchymal stromal cell administration into a cardiopulmonary bypass (CPB) circuit, including a pediatric oxygenator, and to assess the immunomodulatory response of the circulating blood prime. METHODS: mesenchymal stromal cells were injected into the venous reservoir after 80 minutes of perfusion. To assess oxygenator function, immune reaction, and cytokine/chemokine levels, the ex vivo circulation was maintained for 300 minutes after administration. RESULTS: over time. IL-6 level was significantly increased after cell administration. CONCLUSIONS: The administration of mesenchymal stromal cells does not interfere with oxygenator function. Allogeneic mesenchymal stromal cells show no immunogenicity, and increase plasma IL-6 level during ex vivo circulation. Further investigation is necessary to determine the effect of mesenchymal stromal cell delivery through CPB during pediatric cardiac surgery.","journal":"JTCVS Open","year":2021,"id":199802,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9646,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":776831,"name":"Casey M. Briggs","orcid":null,"position":1,"is_corresponding":false},{"id":265277,"name":"Anushree Datar","orcid":null,"position":2,"is_corresponding":false},{"id":617658,"name":"Christine A. Brantner","orcid":"0000-0001-8172-901X","position":3,"is_corresponding":false},{"id":263319,"name":"Patrick J. Hanley","orcid":"0000-0002-0102-7892","position":4,"is_corresponding":false},{"id":603537,"name":"Richard A. Jonas","orcid":"0000-0002-8379-4824","position":5,"is_corresponding":false},{"id":703728,"name":"Nobuyuki Ishibashi","orcid":"0000-0002-7910-4050","position":6,"is_corresponding":false},{"id":776398,"name":"Takuya Maeda","orcid":"0000-0003-0912-4643","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-18T23:50:40.558460Z","pmid":"33899029","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}