{"doi":"10.1016/j.xinn.2023.100526","title":"Decoding the proteostasis network in resistance to KRAS inhibitors","abstract":"The Kirsten rat sarcoma (KRAS) gene, which is one of the most frequently mutated genes in human cancers, has long captured the attention of oncologists. The recent approval of KRAS G12C inhibitors (KRASi), such as sotorasib and adagrasib, has signaled a promising turn in cancer therapy. However, emerging resistance to these drugs presents a formidable challenge.1 Lv et al.’s2 publication in Science suggests that the proteostasis network plays a role in mediating diverse KRASi resistance mechanisms.","journal":"The Innovation","year":2023,"id":385484,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":257789,"name":"Zhuan Zhou","orcid":"0000-0002-9683-5760","position":1,"is_corresponding":false},{"id":363328,"name":"Kenneth D. Westover","orcid":"0000-0003-3653-5923","position":2,"is_corresponding":false},{"id":257788,"name":"Xinxin Song","orcid":"0000-0003-3868-2644","position":0,"is_corresponding":true}],"reference_count":5,"raw_metadata":null,"created_at":"2026-07-19T01:17:52.636565Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}