{"doi":"10.1016/j.xgen.2025.100952","title":"How exposomic tools complement and enrich genomic research","abstract":"Because genetics and the environment interact to drive gene expression, we propose that exposomics must now be incorporated into the multi-omics paradigm to complete the overall biological pathway. Exposomics' groundbreaking tools and life-course framework holistically characterize non-genetic (environment) components of chronic diseases and integrate with multi-omics. This work brings forward the importance of the human exposome as a major driver of gene/protein expression across the life course. Exposome features are noteworthy for multi-omics as they (1) show where and when biodynamic trajectories of gene x environment interactions meet; (2) move beyond single-environmental-factor-centric views; (3) integrate exposomic measurements during and outside of critical windows of susceptibility; (4) provide agnostic discovery and hypothesis-generating studies; and (5) are biodynamic over time. Upon applying these unique features of the human exposome, future human studies are anticipated to revolutionize the integration of genetics and environmental health sciences.","journal":"Cell Genomics","year":2025,"id":519921,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9517,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":282206,"name":"Andrea Baccarelli","orcid":"0000-0002-3436-0640","position":1,"is_corresponding":false},{"id":25018,"name":"Edwin K. Silverman","orcid":"0000-0002-3641-3822","position":2,"is_corresponding":false},{"id":54933,"name":"Robert O. Wright","orcid":"0000-0003-1180-6459","position":3,"is_corresponding":false},{"id":251922,"name":"Konstantinos C. Makris","orcid":"0000-0001-5251-8619","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T02:49:23.618703Z","pmid":"40712569","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}