{"doi":"10.1016/j.xgen.2025.100878","title":"Integrative characterization of MYC RNA-binding function","abstract":"Emerging evidence suggests that MYC interacts with RNAs. Here, we performed an integrative characterization of MYC as an RNA-binding protein in six cell lines. We found that MYC binds to a myriad of RNAs with high affinity for guanosine-rich RNAs. Global and specific depletion of RNAs reduces MYC chromatin occupancy. Mechanistically, two highly conserved sequences, amino acids 355-357 KRR and 364-367 RQRR, within the basic region of MYC are necessary for its RNA binding. Notably, alanine substitution of KRR abolishes MYC's RNA-binding ability both in vitro and in vivo, without affecting its ability to bind E-box DNA as part of the MYC:MAX dimer in vitro. The loss of RNA-binding function decreases MYC chromatin binding in vivo and attenuates its ability to promote gene expression, cell-cycle progression, and proliferation. Our study lays a foundation for future investigation into the role of RNAs in MYC-mediated transcriptional activation and oncogenic functions.","journal":"Cell Genomics","year":2025,"id":518368,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9537,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":355797,"name":"Zehua Wang","orcid":"0000-0002-0769-8865","position":1,"is_corresponding":false},{"id":598411,"name":"Xiaofei Wang","orcid":"0009-0002-7143-0705","position":2,"is_corresponding":false},{"id":24031,"name":"Yifei Wang","orcid":"0000-0002-3313-0974","position":3,"is_corresponding":false},{"id":1385793,"name":"Dhamotharan Pattarayan","orcid":"0000-0003-4995-1264","position":4,"is_corresponding":false},{"id":958663,"name":"Yu Zhang","orcid":"0000-0001-8296-154X","position":5,"is_corresponding":false},{"id":70244,"name":"Phuong L. Nguyen","orcid":null,"position":6,"is_corresponding":false},{"id":1333164,"name":"Avishek Bhuniya","orcid":"0000-0001-6253-0400","position":7,"is_corresponding":false},{"id":645870,"name":"Yuang Chen","orcid":"0000-0001-8733-3948","position":8,"is_corresponding":false},{"id":355116,"name":"Haozhe Huang","orcid":"0000-0001-6765-5931","position":9,"is_corresponding":false},{"id":459944,"name":"Yixian Huang","orcid":"0009-0004-2601-2875","position":10,"is_corresponding":false},{"id":324184,"name":"Luxuan Wang","orcid":"0000-0001-9071-2578","position":11,"is_corresponding":false},{"id":632541,"name":"Junmei Wang","orcid":"0000-0001-8853-7811","position":12,"is_corresponding":false},{"id":355122,"name":"Song Li","orcid":"0000-0003-1658-949X","position":13,"is_corresponding":false},{"id":1082560,"name":"Min Zhang","orcid":"0000-0002-2225-8024","position":14,"is_corresponding":false},{"id":560681,"name":"Yang Liu","orcid":"0000-0002-1109-0756","position":15,"is_corresponding":false},{"id":335267,"name":"Nara Lee","orcid":"0000-0002-5190-6385","position":16,"is_corresponding":false},{"id":355799,"name":"Da Yang","orcid":"0000-0002-8336-9457","position":17,"is_corresponding":false},{"id":289822,"name":"Sihan Li","orcid":"0000-0001-5396-6181","position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-07-19T02:49:09.679930Z","pmid":"40378850","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}