{"doi":"10.1016/j.xgen.2023.100474","title":"Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation","abstract":"Epstein-Barr virus (EBV) and human leukocyte antigen (HLA) polymorphisms are well-known risk factors for nasopharyngeal carcinoma (NPC). However, the combined effects between HLA and EBV on the risk of NPC are unknown. We applied a causal inference framework to disentangle interaction and mediation effects between two host HLA SNPs, rs2860580 and rs2894207, and EBV variant 163364 with a population-based case-control study in NPC-endemic southern China. We discovered the strong interaction effects between the high-risk EBV subtype and both HLA SNPs on NPC risk (rs2860580, relative excess risk due to interaction [RERI] = 4.08, 95% confidence interval [CI] = 2.03-6.14; rs2894207, RERI = 3.37, 95% CI = 1.59-5.15), accounting for the majority of genetic risk effects. These results indicate that HLA genes and the high-risk EBV have joint effects on NPC risk. Prevention strategies targeting the high-risk EBV subtype would largely reduce NPC risk associated with EBV and host genetic susceptibility.","journal":"Cell Genomics","year":2024,"id":423199,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":386029,"name":"Ruimei Feng","orcid":"0000-0001-8020-2654","position":1,"is_corresponding":false},{"id":376437,"name":"Zhonghua Liu","orcid":"0000-0003-3048-9823","position":2,"is_corresponding":false},{"id":235958,"name":"Xiang Zhou","orcid":"0000-0002-5727-6783","position":3,"is_corresponding":false},{"id":1218281,"name":"Yanhong Chen","orcid":"0000-0001-6506-0715","position":4,"is_corresponding":false},{"id":1218282,"name":"Yulu Cao","orcid":"0009-0009-9861-1224","position":5,"is_corresponding":false},{"id":298304,"name":"Linda Valeri","orcid":"0000-0003-0664-1194","position":6,"is_corresponding":false},{"id":218522,"name":"Zilin Li","orcid":"0000-0003-3410-8231","position":7,"is_corresponding":false},{"id":291440,"name":"Zhiwei Liu","orcid":"0000-0002-0136-651X","position":8,"is_corresponding":false},{"id":386034,"name":"Su‐Mei Cao","orcid":"0000-0003-1749-517X","position":9,"is_corresponding":false},{"id":1201645,"name":"Qing Liu","orcid":"0000-0001-5109-0809","position":10,"is_corresponding":false},{"id":386792,"name":"Shang-Hang Xie","orcid":null,"position":11,"is_corresponding":false},{"id":386030,"name":"Ellen T. 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