{"doi":"10.1016/j.xfre.2021.08.008","title":"Impact of an online multicomponent very-low-carbohydrate program in women with polycystic ovary syndrome: a pilot study","abstract":"OBJECTIVE: To study the impact of a very-low-carbohydrate (VLC) diet for 16 weeks in overweight or obese women with polycystic ovary syndrome (PCOS). DESIGN: Single-arm prospective pilot study. SETTING: We recruited participants using medical records from an academic medical center. PATIENTS: ) with PCOS. INTERVENTIONS: We taught participants to follow a VLC diet and provided information about a variety of behavioral skills including mindfulness and positive affect using an online 16-week intervention. MAIN OUTCOME MEASURES: Changes in body weight, glycated hemoglobin, and PCOS-related quality of life. RESULTS: The intervention led to positive health outcomes including decreases in percent weight (mean difference = -7.67, SD = 6.10) and glycated hemoglobin level (mean difference = -0.21%, SD = 0.27), an increase in sex hormone binding globulin level (mean difference = 9.24 nmol/L, SD = 16.34), and increases in PCOS-related quality of life measures, including menstrual predictability (mean difference = 2.10, SD = 2.76) and body hair (mean difference = 1.14, SD = 1.04). The low-density lipoprotein cholesterol level increased (mean difference = 0.23 mmol/L, SD = 0.49). CONCLUSIONS: The results suggest that a VLC dietary intervention has potential to promote both weight loss and glycemic control in overweight and obese adults with PCOS, two key components in the prevention of type 2 diabetes. TRIAL REGISTRATION NUMBER: NCT03987854.","journal":"F&S Reports","year":2021,"id":193240,"datarank":0.4931544808436173,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.12041848337541715,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.12041848337541715,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":10,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9252,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03987854"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":761113,"name":"Alison O’Brien","orcid":"0000-0002-8185-8118","position":1,"is_corresponding":false},{"id":761593,"name":"Haley Maser","orcid":null,"position":2,"is_corresponding":false},{"id":761594,"name":"Amreen Kanwal","orcid":null,"position":3,"is_corresponding":false},{"id":413817,"name":"Hovig Bayandorian","orcid":"0000-0003-4596-0323","position":4,"is_corresponding":false},{"id":761595,"name":"Symone Martin","orcid":null,"position":5,"is_corresponding":false},{"id":761596,"name":"Paige Carrigan","orcid":null,"position":6,"is_corresponding":false},{"id":761597,"name":"Rebecca McNamee","orcid":null,"position":7,"is_corresponding":false},{"id":413814,"name":"Jennifer Daubenmier","orcid":"0000-0001-5678-4068","position":8,"is_corresponding":false},{"id":521761,"name":"Deanna J. M. Isaman","orcid":null,"position":9,"is_corresponding":false},{"id":232456,"name":"Vasantha Padmanabhan","orcid":"0000-0002-8443-7212","position":10,"is_corresponding":false},{"id":491218,"name":"Yolanda R. Smith","orcid":null,"position":11,"is_corresponding":false},{"id":413818,"name":"James E. Aikens","orcid":"0000-0002-3795-9018","position":12,"is_corresponding":false},{"id":413811,"name":"Laura R. Saslow","orcid":"0000-0003-3991-3205","position":13,"is_corresponding":false},{"id":413816,"name":"Amanda L. Missel","orcid":"0000-0002-9879-0519","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-18T23:49:47.463744Z","pmid":"34934978","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}