{"doi":"10.1016/j.xfre.2021.03.003","title":"Racial differences in anxiety, depression, and quality of life in women with polycystic ovary syndrome","abstract":"OBJECTIVE: To evaluate racial differences in the anxiety and depression prevalence and scores in women with polycystic ovary syndrome (PCOS). DESIGN: Cross-sectional. SETTING: Academic institution. PATIENTS: Reproductive-aged women with PCOS (n = 272) and controls (n = 295). INTERVENTIONS: Hospital anxiety and depression scale and modified PCOS quality-of-life survey (MPCOS-Q). MAIN OUTCOME MEASURES: Differences in depression and anxiety scores and quality-of-life score measured using the hospital anxiety and depression scale and MPCOS-Q were determined between White and Black women with PCOS. Multivariable correlation regressions assessed the association of the Ferriman-Gallwey score, total testosterone, body mass index (BMI), and homeostatic model assessment of insulin resistance with anxiety, depression, and quality-of-life scores. RESULTS: Multivariable regression controlling for age, BMI, and socioeconomic status showed that White women with PCOS had a significantly higher prevalence of anxiety than Black women with PCOS (75.9% vs. 61.3%) and significantly higher anxiety scores (mean ± SD, 10.3 ± 4.1 vs. 8.7 ± 4.6). The prevalence of depression (24.4% vs. 29%) and depression scores (4.8 ± 3.6 vs. 5.1 ± 4.0) was not significantly different. In multivariable correlation regressions, the interaction between BMI and race in its association with anxiety scores was significant. The association of race with Ferriman-Gallwey score, total testosterone, or homeostatic model assessment of insulin resistance was not significant. In multivariable models, although the total MPCOS-Q scores were similar, the infertility domain was significantly lower in Black women with PCOS (mean ± SD, 12.6 ± 7.8 vs. 17.5 ± 6.8) indicating a lower quality of life related to infertility. CONCLUSION: Racial differences identified in the prevalence of anxiety and MPCOS-Q domains suggest the importance of routine screening and provide an opportunity for targeted interventions based on race.","journal":"F&S Reports","year":2021,"id":167220,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8343,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":603225,"name":"Iris Lee","orcid":"0000-0002-4319-4429","position":1,"is_corresponding":false},{"id":450796,"name":"Anat Chemerinski","orcid":"0000-0002-8745-9409","position":2,"is_corresponding":false},{"id":694054,"name":"Chang Liu","orcid":"0000-0001-8860-3188","position":3,"is_corresponding":false},{"id":694609,"name":"Jenna Lipson","orcid":null,"position":4,"is_corresponding":false},{"id":285070,"name":"Kelly C. Allison","orcid":"0000-0002-9807-0220","position":5,"is_corresponding":false},{"id":331682,"name":"Robert Gallop","orcid":"0000-0001-9986-2994","position":6,"is_corresponding":false},{"id":334360,"name":"Anuja Dokras","orcid":"0000-0002-1085-3969","position":7,"is_corresponding":false},{"id":334358,"name":"Snigdha Alur-Gupta","orcid":"0000-0002-2445-4571","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-18T23:45:54.042727Z","pmid":"34278359","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}