{"doi":"10.1016/j.xcrm.2025.102472","title":"Optimal post-treatment surveillance strategy for human papillomavirus-positive oropharyngeal cancer","abstract":"The objective of the current study was to determine the optimal individualized surveillance strategies for human papillomavirus (HPV)-positive oropharyngeal cancer. A consecutive cohort of 1,146 HPV-positive oropharyngeal cancer patients treated by intensity-modulated radiation therapy between 2013 and 2023 was included. The primary endpoint was the power of detecting recurrence at each follow-up. Three distinct, stage-specific follow-up strategies were developed based on the monthly probability of disease recurrence. Over a 5-year post-treatment period, the total number of follow-up visits was 10, 11, and 12 for Stages I, II, and III, respectively. These risk-adapted follow-up strategies demonstrated superior detection efficiency when compared to existing clinical guidelines. Furthermore, validation using Markov decision-analytic models confirmed that the risk-based strategies were both more effective and cost-efficient than the guideline-recommended strategy. Compared to the surveillance strategies recommended by the clinical guidelines, our proposed approach for HPV-positive oropharyngeal cancer demonstrated greater cost-effectiveness.","journal":"Cell Reports Medicine","year":2025,"id":583743,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9489,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":255786,"name":"Eric J. Sherman","orcid":"0000-0002-4960-4783","position":1,"is_corresponding":false},{"id":236122,"name":"Nadeem Riaz","orcid":"0000-0001-9873-5862","position":2,"is_corresponding":false},{"id":255799,"name":"Sean M. McBride","orcid":"0000-0002-9676-1669","position":3,"is_corresponding":false},{"id":490682,"name":"Yao Yu","orcid":"0000-0002-2814-4482","position":4,"is_corresponding":false},{"id":689882,"name":"A. Shamseddine","orcid":"0000-0003-3686-5850","position":5,"is_corresponding":false},{"id":244003,"name":"Winston Wong","orcid":null,"position":6,"is_corresponding":false},{"id":348658,"name":"Lara Dunn","orcid":"0000-0001-5318-2571","position":7,"is_corresponding":false},{"id":255810,"name":"Nancy Y. Lee","orcid":"0000-0003-3044-9522","position":8,"is_corresponding":false},{"id":1496288,"name":"Caineng Cao","orcid":"0000-0002-2803-0864","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:59:07.970345Z","pmid":"41330378","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}