{"doi":"10.1016/j.xcrm.2025.102433","title":"Modeling antithymocyte globulin-induced microvasculopathy using human iPSC-derived vascularized liver organoids","abstract":null,"journal":"Cell Reports Medicine","year":2025,"id":617913,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":231615,"name":"Yosuke Yoneyama","orcid":"0000-0002-9170-2846","position":1,"is_corresponding":false},{"id":231614,"name":"Norikazu Saiki","orcid":"0000-0002-0830-4848","position":2,"is_corresponding":false},{"id":1045867,"name":"Yunheng Wu","orcid":null,"position":3,"is_corresponding":false},{"id":1045228,"name":"Chiharu Moriya","orcid":"0000-0002-0723-4040","position":4,"is_corresponding":false},{"id":1593714,"name":"Rio Ohmura","orcid":null,"position":5,"is_corresponding":false},{"id":234211,"name":"Mari Maezawa","orcid":null,"position":6,"is_corresponding":false},{"id":1593715,"name":"Yoshihiro Shimada","orcid":null,"position":7,"is_corresponding":false},{"id":178734,"name":"Yicheng Wang","orcid":null,"position":8,"is_corresponding":false},{"id":1045239,"name":"Kensaku Mori","orcid":"0000-0002-0100-4797","position":9,"is_corresponding":false},{"id":1593716,"name":"Noriki Okada","orcid":null,"position":10,"is_corresponding":false},{"id":1593717,"name":"Yasuharu Onishi","orcid":null,"position":11,"is_corresponding":false},{"id":1593718,"name":"Yukihiro Sanada","orcid":null,"position":12,"is_corresponding":false},{"id":1593719,"name":"Yuta Hirata","orcid":null,"position":13,"is_corresponding":false},{"id":1593720,"name":"Yasunaru Sakuma","orcid":null,"position":14,"is_corresponding":false},{"id":231623,"name":"Takanori Takebe","orcid":"0000-0002-6989-3041","position":15,"is_corresponding":false},{"id":1045859,"name":"Shuntaro Kawamura","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Modeling antithymocyte globulin-induced microvasculopathy using human iPSC-derived vascularized liver organoids","abstract":"Antithymocyte globulin (ATG) is a widely used immunosuppressive agent, yet its off-target vascular effects remain a clinical challenge in part due to a lack of relevant human models. Here, we uncover a biphasic mechanism of ATG-induced microvasculopathy using a humanized liver organoid platform derived from induced pluripotent stem cells (iPSCs). We show that ATG triggers a rapid, complement-dependent phase of injury restricted to human iPSC-derived liver sinusoidal endothelial cells (iLSECs), leading to C3 deposition and acute thrombosis specifically in human but not in mouse vessels. Transcriptomics reveals a delayed transforming growth factor β (TGF-β) pathway-driven proinflammatory program that coincides with neutrophil recruitment and degranulation, while pharmacological TGF-β blockade attenuates thrombosis and flow disturbance. Our findings reveal a pathogenic sequence of complement and TGF-β pathway activation and establish a translational platform for dissecting human liver-specific microvasculopathy in vivo.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41202806","pmcid":"PMC12711670","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"","title":null},{"funder_name":"Japan Agency for Medical Research and Development","grant_id":"","title":null},{"funder_name":"Japan Science and Technology Agency Moonshot Research and Development Program","grant_id":"","title":null}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S2666379125005063?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2666379125005063?httpAccept=text/plain","host_type":"publisher"},{"url":"https://europepmc.org/articles/PMC12711670","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12711670?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":["Liver","Organoids","Neutrophils","Cell Line","Endothelial Cells","Animals","Humans","Mice","Hepatic Veno-Occlusive Disease","Thrombosis","Transforming Growth Factor beta","Immunosuppressive Agents","Antilymphocyte Serum","Liver Transplantation","Signal Transduction","Graft Rejection","Adult","Complement C3","Female","Male","Microvessels","Young Adult","Induced Pluripotent Stem Cells"],"keywords":["Complement","TGF-β","Intravital Imaging","Liver Sinusoidal Endothelial Cell","ATG","Induced Pluripotent Stem Cell","Sos","Microvasculopathy","Organoid","Immunothrombosis"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"},{"name":"gen"},{"name":"cellosaurus"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T02:55:58.345931Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}