{"doi":"10.1016/j.xcrm.2023.100975","title":"Pre-existing Fc profiles shape the evolution of neutralizing antibody breadth following influenza vaccination","abstract":"Under the ever-present threat of a pandemic influenza strain, the evolution of a broadly reactive, neutralizing, functional, humoral immune response may hold the key to protection against both circulating and emerging influenza strains. We apply a systems approach to profile hemagglutinin- and neuraminidase-specific humoral signatures that track with the evolution of broad immunity in a cohort of vaccinated individuals and validate these findings in a second longitudinal cohort. Multivariate analysis reveals the presence of a unique pre-existing Fcγ-receptor-binding antibody profile in individuals that evolved broadly reactive hemagglutination inhibition activity (HAI), marked by the presence of elevated levels of pre-existing FCGR2B-binding antibodies. Moreover, vaccination with FCGR2B-binding antibody-opsonized influenza results in enhanced antibody titers and HAI activity in a murine model. Together, these data suggest that pre-existing FCGR2B binding antibodies are a key correlate of the evolution of broadly protective influenza-specific antibodies, providing insight for the design of next-generation influenza vaccines.","journal":"Cell Reports Medicine","year":2023,"id":361851,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":106725,"name":"John S. Burke","orcid":"0000-0003-1282-8211","position":1,"is_corresponding":false},{"id":1115022,"name":"Alexander L. Roederer","orcid":null,"position":2,"is_corresponding":false},{"id":321856,"name":"Matthew J. Gorman","orcid":null,"position":3,"is_corresponding":false},{"id":745244,"name":"Sophia T. Mundle","orcid":null,"position":4,"is_corresponding":false},{"id":104358,"name":"Daniel Lingwood","orcid":"0000-0001-5631-9238","position":5,"is_corresponding":false},{"id":744386,"name":"Simon Delagrave","orcid":"0000-0003-0865-2196","position":6,"is_corresponding":false},{"id":1047522,"name":"Saranya Sridhar","orcid":"0000-0002-4267-3102","position":7,"is_corresponding":false},{"id":245069,"name":"Ted M. Ross","orcid":"0000-0003-1947-7469","position":8,"is_corresponding":false},{"id":618120,"name":"Harry Kleanthous","orcid":"0000-0001-7115-235X","position":9,"is_corresponding":false},{"id":805827,"name":"Galit Alter","orcid":"0000-0002-9221-6735","position":10,"is_corresponding":false},{"id":420227,"name":"Carolyn M. Boudreau","orcid":"0000-0001-5006-3067","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":null,"created_at":"2026-07-19T01:14:15.063476Z","pmid":"36921600","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}