{"doi":"10.1016/j.xcrm.2021.100321","title":"Broad auto-reactive IgM responses are common in critically ill patients, including those with COVID-19","abstract":", including pulmonary endothelial and epithelial cells. By using a combination of flow cytometry, analytical proteome microarray technology, and lactose dehydrogenase (LDH)-release cytotoxicity assays, we identify high-affinity, complement-fixing, auto-reactive IgM directed against 260 candidate autoantigens, including numerous molecules preferentially expressed on the cellular membranes of pulmonary, vascular, gastrointestinal, and renal tissues. These findings suggest that broad IgM-mediated autoimmune reactivity may be involved in the pathogenesis of severe COVID-19, thereby identifying a potential target for therapeutic interventions.","journal":"Cell Reports Medicine","year":2021,"id":175457,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":716568,"name":"Isaac Woodhouse","orcid":"0000-0002-8221-7697","position":1,"is_corresponding":false},{"id":716569,"name":"David Schneider","orcid":"0000-0002-9935-740X","position":2,"is_corresponding":false},{"id":247225,"name":"Deanna A. Kulpa","orcid":"0000-0002-0411-7295","position":3,"is_corresponding":false},{"id":233497,"name":"Guido Silvestri","orcid":"0000-0001-6602-2470","position":4,"is_corresponding":false},{"id":388038,"name":"Cheryl L. Maier","orcid":"0000-0003-4044-2674","position":5,"is_corresponding":false},{"id":323205,"name":"Andrew Kam Ho Wong","orcid":"0000-0001-7378-0288","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T23:47:15.431199Z","pmid":"34075365","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}