{"doi":"10.1016/j.xcrm.2020.100126","title":"Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike","abstract":"SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths. The Spike glycoproteins of SARS-CoV-2 mediate viral entry and are the main targets for neutralizing antibodies. Understanding the antibody response directed against SARS-CoV-2 is crucial for the development of vaccine, therapeutic, and public health interventions. Here, we perform a cross-sectional study on 106 SARS-CoV-2-infected individuals to evaluate humoral responses against SARS-CoV-2 Spike. Most infected individuals elicit anti-Spike antibodies within 2 weeks of the onset of symptoms. The levels of receptor binding domain (RBD)-specific immunoglobulin G (IgG) persist over time, and the levels of anti-RBD IgM decrease after symptom resolution. Although most individuals develop neutralizing antibodies within 2 weeks of infection, the level of neutralizing activity is significantly decreased over time. Our results highlight the importance of studying the persistence of neutralizing activity upon natural SARS-CoV-2 infection.","journal":"Cell Reports Medicine","year":2020,"id":49756,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":233,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9599,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":241564,"name":"Romain Gasser","orcid":"0000-0002-8565-1106","position":1,"is_corresponding":false},{"id":241565,"name":"Guillaume Beaudoin-Bussières","orcid":"0000-0002-8092-4101","position":2,"is_corresponding":false},{"id":241566,"name":"Jonathan Richard","orcid":"0000-0002-9015-9589","position":3,"is_corresponding":false},{"id":241567,"name":"Ralf Duerr","orcid":"0000-0001-9569-9237","position":4,"is_corresponding":false},{"id":241568,"name":"Annemarie Laumaea","orcid":"0000-0002-4934-597X","position":5,"is_corresponding":false},{"id":241569,"name":"Sai Priya Anand","orcid":"0000-0002-7759-9803","position":6,"is_corresponding":false},{"id":241570,"name":"Guillaume Goyette","orcid":"0000-0003-3277-568X","position":7,"is_corresponding":false},{"id":241571,"name":"Mehdi Benlarbi","orcid":"0000-0001-9966-3784","position":8,"is_corresponding":false},{"id":241572,"name":"Shilei Ding","orcid":"0000-0003-1895-5131","position":9,"is_corresponding":false},{"id":243836,"name":"Halima Medjahed","orcid":null,"position":10,"is_corresponding":false},{"id":241573,"name":"Antoine Lewin","orcid":"0000-0003-1748-4198","position":11,"is_corresponding":false},{"id":241574,"name":"Josée Perreault","orcid":"0000-0002-9434-2348","position":12,"is_corresponding":false},{"id":243837,"name":"Tony Tremblay","orcid":null,"position":13,"is_corresponding":false},{"id":241575,"name":"Gabrielle Gendron‐Lepage","orcid":"0000-0002-2671-3872","position":14,"is_corresponding":false},{"id":241576,"name":"Nicolas Gauthier","orcid":"0000-0001-5217-2769","position":15,"is_corresponding":false},{"id":104084,"name":"Marc Carrier","orcid":"0000-0001-8296-2972","position":16,"is_corresponding":false},{"id":243838,"name":"Diane Marcoux","orcid":null,"position":17,"is_corresponding":false},{"id":70003,"name":"Alain Piché","orcid":"0000-0002-6313-4538","position":18,"is_corresponding":false},{"id":243839,"name":"Myriam Lavoie","orcid":null,"position":19,"is_corresponding":false},{"id":241577,"name":"Alexandre Benoît","orcid":"0000-0002-0627-4948","position":20,"is_corresponding":false},{"id":243840,"name":"Vilayvong Loungnarath","orcid":null,"position":21,"is_corresponding":false},{"id":243841,"name":"Gino Brochu","orcid":null,"position":22,"is_corresponding":false},{"id":241578,"name":"Élie Haddad","orcid":"0000-0003-2446-6879","position":23,"is_corresponding":false},{"id":241579,"name":"Hannah D. 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