{"doi":"10.1016/j.vph.2009.09.001","title":"Interaction between bone morphogenetic proteins and endothelin-1 in human pulmonary artery smooth muscle","abstract":null,"journal":"Vascular Pharmacology","year":2009,"id":624633,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1614760,"name":"Padmini Sarathchandra","orcid":null,"position":1,"is_corresponding":false},{"id":472794,"name":"Magdi H. Yacoub","orcid":"0000-0001-9070-8245","position":2,"is_corresponding":false},{"id":1614761,"name":"Adrian H. Chester","orcid":null,"position":3,"is_corresponding":false},{"id":1614759,"name":"Sarah Din","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Interaction between bone morphogenetic proteins and endothelin-1 in human pulmonary artery smooth muscle","abstract":"Genetic mutations in bone morphogenetic protein receptor 2 (BMPR2) have been shown to occur in patients with familial and idiopathic pulmonary arterial hypertension (PAH). However the interactions between ligands for this receptor and other mediators implicated in heritable PAH have not been investigated. This study examines the regulation of endothelin-1 (ET-1), a potent vasoconstrictor and comitogen that is implicated in the pathogenesis of heritable PAH, by ligands for the BMPR2. Immunohistochemical studies showed that pulmonary artery segments removed from normotensive human lungs express BMPR2 and bone morphogenetic proteins 2, 4 and 7 (BMP2, BMP4 and BMP7). In the presence of BMP7 and BMP4 there was a significant inhibition of ET-1 release, induced by cytokines, from cultured pulmonary artery smooth muscle cells. Fresh ring segments of pulmonary artery were assessed for their response to ET-1 in the presence and absence of BMP2, BMP4 and BMP7. BMP7 inhibited contraction in response to ET-1 in a concentration-dependent manner. BMP2 and BMP4 had no significant effect on the response to ET-1. These results suggest that BMP7 has the ability to regulate the effects of endothelin-1 in the pulmonary circulation. Genetic mutations in BMPR2 may lead to a loss of these regulatory mechanisms and contribute to the pathogenesis of pulmonary hypertension.","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19786120","pmcid":null,"openalex_id":"https://openalex.org/W2043452178","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"","title":null},{"funder_name":"Medical Research Council","grant_id":"","title":null}],"total_grants":2,"fwci":0.4921,"citation_percentile":0.71498259,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2016,"count":3},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2024,"count":3},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1537189109001049?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1537189109001049?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.vph.2009.09.001","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19786120","host_type":"repository"}],"fields_of_study":["Pulmonary Hypertension Research and Treatments","Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","Vascular Anomalies and Treatments","Adult","Aged","Bone Morphogenetic Protein 7","Bone Morphogenetic Protein Receptors, Type II","Bone Morphogenetic Proteins","Cells, Cultured","Endothelin-1","Female","Humans","Hypertension, Pulmonary","Immunohistochemistry","Male","Middle Aged","Muscle, Smooth, Vascular","Pulmonary Artery","Vasoconstriction"],"mesh_terms":["Adult","Aged","Cells, Cultured","Female","Humans","Hypertension, Pulmonary","Immunohistochemistry","Male","Middle Aged","Muscle, Smooth, Vascular","Pulmonary Artery","Vasoconstriction","Endothelin-1","Bone Morphogenetic Proteins","Bone Morphogenetic Protein Receptors, Type II","Bone Morphogenetic Protein 7"],"keywords":["BMPR2","Bone morphogenetic protein","Bone morphogenetic protein receptor","Bone morphogenetic protein 2","Pulmonary artery","Endothelin 1","Bone morphogenetic protein 7","Pathogenesis","Pulmonary hypertension","Endothelin receptor","Internal medicine","Endocrinology","Medicine","Receptor","Biology","Gene","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T04:23:24.106394Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}