{"doi":"10.1016/j.virusres.2009.08.008","title":"Inhibition of hepatitis C virus IRES-mediated translation by oligonucleotides","abstract":null,"journal":"Virus Research","year":2009,"id":589263,"datarank":0.45718117024655824,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.21576548338144316,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.21576548338144316,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":320713,"name":"Steffen Mueller","orcid":"0000-0003-2660-258X","position":1,"is_corresponding":false},{"id":174716,"name":"Eckard Wimmer","orcid":null,"position":2,"is_corresponding":false},{"id":7410,"name":"Xiaoyu Li","orcid":"0009-0006-9840-6704","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Inhibition of hepatitis C virus IRES-mediated translation by oligonucleotides","abstract":"Two oligodeoxynucleotides (ODNs) were found to have a strong inhibition on the hepatitis C virus (HCV) internal ribosomal entry sites (IRES)-mediated translation but not the rabbit globin mRNA translation. Specific inhibition of those ODNs on HCV IRES-mediated translation was confirmed with heat treatment of ODNs in formic acid and dosage-dependent manners. Heat treatment of ODNs presented a decreasing inhibitory effect on HCV IRES-mediated translation. A dosage-dependent decrease of HCV IRES-mediated translation was observed with increasing amount of these ODNs in HeLa cell extracts. The minimal sequences of ODNs (A11) were identified as 5'-CGCGTTACG-3' with the strongest inhibition of the HCV IRES-mediated translation. In a search for cellular factors, two cellular factors (p68 and p70) were identified to interact with ODNs A1 and A11, but not A5 (CT-oligo). This data showed new kinds of cellular proteins involved in HCV IRES-mediated translation. Further study of ODNs and these cellular proteins will provide important information for understanding the mechanistic basis and molecular regulation of HCV IRES-mediated translation.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19720092","pmcid":null,"openalex_id":"https://openalex.org/W2016110292","authors":[],"funders":[],"total_grants":0,"fwci":0.356,"citation_percentile":0.65413093,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2018,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0168170209002950?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0168170209002950?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.virusres.2009.08.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19720092","host_type":"repository"}],"fields_of_study":["Viral Infections and Immunology Research","RNA and protein synthesis mechanisms","RNA modifications and cancer","Antiviral Agents","Dose-Response Relationship, Drug","HeLa Cells","Hepacivirus","Host-Pathogen Interactions","Humans","Oligonucleotides","Protein Biosynthesis"],"mesh_terms":["Antiviral Agents","Dose-Response Relationship, Drug","HeLa Cells","Humans","Oligonucleotides","Protein Biosynthesis","Hepacivirus","Host-Pathogen Interactions","Hela Cells"],"keywords":["Internal ribosome entry site","Translation (biology)","Biology","Eukaryotic translation","Protein biosynthesis","Oligonucleotide","Molecular biology","Messenger RNA","HeLa","Virology","Cell biology","Cell","Gene","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-23T15:17:55.732250Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}