{"doi":"10.1016/j.virol.2018.10.004","title":"Identification of structural glycoprotein E2 domain critical to mediate replication of Classical Swine Fever Virus in SK6 cells","abstract":null,"journal":"Virology","year":2019,"id":596738,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1528406,"name":"L.G. Holinka","orcid":null,"position":1,"is_corresponding":false},{"id":1528409,"name":"E. Ramirez-Medina","orcid":null,"position":2,"is_corresponding":false},{"id":1528412,"name":"G.R. Risatti","orcid":null,"position":3,"is_corresponding":false},{"id":1528416,"name":"E.A. Vuono","orcid":null,"position":4,"is_corresponding":false},{"id":1528420,"name":"K.A. Berggren","orcid":null,"position":5,"is_corresponding":false},{"id":1528423,"name":"D.P. Gladue","orcid":null,"position":6,"is_corresponding":false},{"id":1528403,"name":"M.V. Borca","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Identification of structural glycoprotein E2 domain critical to mediate replication of Classical Swine Fever Virus in SK6 cells","abstract":"Envelope glycoprotein E2 of Classical Swine Fever Virus (CSFV) is involved in several critical virus functions. To analyze the role of E2 in virus replication, a series of recombinant CSFVs harboring chimeric forms of E2 CSFV and Bovine viral diarrhea virus (BVDV) were created and tested for their ability to infect swine or bovine cell lines. Substitution of native CSFV E2 by BVDV E2 abrogates virus replication in both cell lines. Substitution of individual domains in CSFV Brescia E2 by the homologous from BVDV produces chimeras that efficiently replicate in SK6 cells with the exception of a chimera harboring BVDV E2 residues 93-168. Further mapping revealed a critical area in E2 required for CSFV replication in SK6 cells between protein residues 136-156. This is the first report categorically defining a discrete portion of E2 as essential to pestivirus infection in susceptible cells.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30340154","pmcid":null,"openalex_id":"https://openalex.org/W2897913823","authors":[],"funders":[{"funder_name":"DOE","grant_id":"DE-SC0014664","title":null},{"funder_name":"ORAU","grant_id":"","title":null}],"total_grants":2,"fwci":3.0407,"citation_percentile":0.91345652,"influential_citations":0,"citation_trend":[{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":6},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"green","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://www.osti.gov/biblio/1580760","host_type":"repository"},{"url":"https://www.osti.gov/biblio/1580760","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S004268221830309X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S004268221830309X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.virol.2018.10.004","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30340154","host_type":"repository"}],"fields_of_study":["Animal Disease Management and Epidemiology","Viral Infections and Immunology Research","Viral gastroenteritis research and epidemiology","Amino Acid Sequence","Amino Acid Substitution","Animals","Cattle","Cell Line","Classical Swine Fever Virus","Diarrhea Viruses, Bovine Viral","Host Specificity","Pestivirus Infections","Protein Domains","Reassortant Viruses","Swine","Viral Envelope Proteins","Virus Replication"],"mesh_terms":["Protein Domains","Amino Acid Sequence","Animals","Diarrhea Viruses, Bovine Viral","Cattle","Cell Line","Classical Swine Fever Virus","Swine","Viral Envelope Proteins","Virus Replication","Reassortant Viruses","Pestivirus Infections","Amino Acid Substitution","Host Specificity","Classical swine fever virus"],"keywords":["Classical swine fever","Virology","Biology","Pestivirus","Virus","Viral replication","Chimera (genetics)","Glycoprotein","Flaviviridae","Recombinant DNA","Togaviridae","Molecular biology","Genetics","Hepatitis C virus","Gene","Classical swine fever virus","E2","Bovine viral diarrhea virus","CSFV","BVDV"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T11:08:02.478722Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}