{"doi":"10.1016/j.virol.2018.03.023","title":"Inhibition of vaccinia virus replication by nitazoxanide","abstract":null,"journal":"Virology","year":2018,"id":653095,"datarank":0.515098080672772,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.0,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":854007,"name":"Daciana Margineantu","orcid":null,"position":1,"is_corresponding":false},{"id":484077,"name":"David M. Hockenbery","orcid":null,"position":2,"is_corresponding":false},{"id":478828,"name":"Julian A. Simon","orcid":"0000-0001-9235-7565","position":3,"is_corresponding":false},{"id":585447,"name":"Adam P. Geballe","orcid":"0000-0002-9279-6653","position":4,"is_corresponding":false},{"id":679438,"name":"Sarah E. Hickson","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Inhibition of vaccinia virus replication by nitazoxanide","abstract":"Nitazoxanide (NTZ) is an FDA-approved anti-protozoal drug that inhibits several bacteria and viruses as well. However, its effect on poxviruses is unknown. Therefore, we investigated the impact of NTZ on vaccinia virus (VACV). We found that NTZ inhibits VACV production with an EC<sub>50</sub> of ~2 μM, a potency comparable to that reported for several other viruses. The inhibitory block occurs early during the viral life cycle, prior to viral DNA replication. The mechanism of viral inhibition is likely not due to activation of intracellular innate immune pathways, such as protein kinase R (PKR) or interferon signaling, contrary to what has been suggested to mediate the effects of NTZ against some other viruses. Rather, our finding that addition of exogenous palmitate partially rescues VACV production from the inhibitory effect of NTZ suggests that NTZ impedes adaptations in cellular metabolism that are needed for efficient completion of the VACV replication cycle.","is_dataset_classified":null,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29625403","pmcid":"PMC5929478","openalex_id":"https://openalex.org/W2795836284","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"RO1AI027762","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI026672","title":null}],"total_grants":2,"fwci":2.4519,"citation_percentile":0.8862681,"influential_citations":0,"citation_trend":[{"year":2019,"count":6},{"year":2020,"count":10},{"year":2021,"count":5},{"year":2022,"count":5},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"bronze","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0042682218301028/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0042682218301028/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0042682218301028?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0042682218301028?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.virol.2018.03.023","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29625403","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5929478","host_type":"repository"}],"fields_of_study":["Poxvirus research and outbreaks","Herpesvirus Infections and Treatments","Virus-based gene therapy research","Antiviral Agents","Cells, Cultured","Fibroblasts","Humans","Nitro Compounds","Thiazoles","Vaccinia virus","Virus Replication"],"mesh_terms":["Antiviral Agents","Cells, Cultured","Fibroblasts","Humans","Nitro Compounds","Thiazoles","Vaccinia virus","Virus Replication"],"keywords":["Vaccinia","Biology","Viral replication","Virology","Virus","Interferon","Viral life cycle","Nitazoxanide","Innate immune system","Viral entry","Immune system","Immunology","Gene","Genetics","Metabolism","Vaccinia virus","Palmitate","Protein Kinase R"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Responsible consumption and production"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T19:03:02.878941Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}