{"doi":"10.1016/j.virol.2017.12.015","title":"Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells","abstract":null,"journal":"Virology","year":2018,"id":595613,"datarank":0.863361332038037,"base_score":5.755742213586912,"endowment":5.755742213586912,"self_citation_contribution":0.863361332038037,"citation_network_contribution":0.0,"self_endowment_contribution":0.863361332038037,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":315,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":107997,"name":"Gary R. Whittaker","orcid":"0000-0001-8037-3816","position":1,"is_corresponding":false},{"id":1525233,"name":"Jean Kaoru Millet","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells","abstract":"During viral entry, enveloped viruses require the fusion of their lipid envelope with host cell membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) protein, a class I viral fusion protein that has several unique features. Coronavirus entry is unusual in that it is often biphasic in nature, and can occur at or near the cell surface or in late endosomes. Recent advances in structural, biochemical and molecular biology of the coronavirus S protein has shed light on the intricacies of coronavirus entry, in particular the molecular triggers of coronavirus S-mediated membrane fusion. Furthermore, characterization of the coronavirus fusion peptide (FP), the segment of the fusion protein that inserts to a target lipid bilayer during membrane fusion, has revealed its particular attributes which imparts some of the unusual properties of the S protein, such as Ca<sup>2+</sup>-dependency. These unusual characteristics can explain at least in part the biphasic nature of coronavirus entry. In this review, using severe acute respiratory syndrome coronavirus (SARS-CoV) as model virus, we give an overview of advances in research on the coronavirus fusion peptide with an emphasis on its role and properties within the biological context of host cell entry.","is_dataset_classified":null,"base_score":5.755742213586912,"endowment":5.755742213586912,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29275820","pmcid":"PMC7112017","openalex_id":"https://openalex.org/W2777577494","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"R21 AI1076258","title":null},{"funder_name":"National Institutes of Health","grant_id":"R21 AI111085","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R21 AI107258","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R21AI111085-01","title":"Spike protein cleavage-activation and emergence of coronaviruses with extended tr"}],"total_grants":4,"fwci":16.1199,"citation_percentile":0.9964273,"influential_citations":0,"citation_trend":[{"year":2018,"count":4},{"year":2019,"count":4},{"year":2020,"count":96},{"year":2021,"count":92},{"year":2022,"count":55},{"year":2023,"count":34},{"year":2024,"count":20},{"year":2025,"count":8},{"year":2026,"count":2}],"oa_status":"closed","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0042682217304208?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0042682217304208?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.virol.2017.12.015","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29275820","host_type":"repository"},{"url":"https://hal.inrae.fr/hal-02623971","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7112017","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7112017","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7112017?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1016/j.virol.2017.12.015","host_type":""},{"url":"https://dx.doi.org/10.1016/j.virol.2017.12.015","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.virol.2017.12.015","host_type":""}],"fields_of_study":["SARS-CoV-2 and COVID-19 Research","Animal Virus Infections Studies","COVID-19 Clinical Research Studies","0301 basic medicine","0303 health sciences","03 medical and health sciences","Cell Membrane","Humans","Membrane Fusion","Severe acute respiratory syndrome-related coronavirus","Spike Glycoprotein, Coronavirus","Viral Envelope Proteins","Virus Internalization"],"mesh_terms":["Cell Membrane","Humans","Membrane Fusion","Viral Envelope Proteins","Severe acute respiratory syndrome-related coronavirus","Virus Internalization","Spike Glycoprotein, Coronavirus"],"keywords":["Lipid bilayer fusion","Coronavirus","Biology","Viral envelope","Viral entry","Context (archaeology)","Cell biology","Endosome","Fusion mechanism","Lipid bilayer","Virology","Virus","Coronavirus disease 2019 (COVID-19)","Membrane","Biochemistry","Viral replication","Calcium","Fusion peptide","Spike protein","SARS","virus entry","Endosomes","570","[SDV]Life Sciences [q-bio]","Cell Membrane","Virus Internalization","Membrane Fusion","Article","Severe acute respiratory syndrome-related coronavirus","Viral Envelope Proteins","616","Spike Glycoprotein, Coronavirus","Humans"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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