{"doi":"10.1016/j.virol.2007.05.008","title":"Heterogeneous nuclear ribonuclear protein K interacts with Sindbis virus nonstructural proteins and viral subgenomic mRNA","abstract":null,"journal":"Virology","year":2007,"id":616909,"datarank":3.685807745610152,"base_score":4.454347296253507,"endowment":4.454347296253507,"self_citation_contribution":0.6681520944380261,"citation_network_contribution":3.0176556511721255,"self_endowment_contribution":0.6681520944380261,"citer_contribution":3.0176556511721255,"corpus_percentile":null,"corpus_rank":null,"citation_count":85,"citer_count":76,"citers_with_citation_signal":70,"citers_with_endowment":70,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1503373,"name":"Lei Gong","orcid":"0000-0001-6017-8490","position":1,"is_corresponding":false},{"id":133520,"name":"Richard W. Hardy","orcid":null,"position":2,"is_corresponding":false},{"id":1590697,"name":"Andrew J. Burnham","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Heterogeneous nuclear ribonuclear protein K interacts with Sindbis virus nonstructural proteins and viral subgenomic mRNA","abstract":"Alphaviruses are a group of arthropod-borne human and animal pathogens that can cause epidemics of significant public health and economic consequence. Alphavirus RNA synthesis requires four virally encoded nonstructural proteins and probably a number of cellular proteins. Using comparative two-dimensional electrophoresis we were able to identify proteins enriched in cytoplasmic membrane fractions containing viral RNA synthetic complexes following infection with Sindbis virus. Our studies demonstrated the following: (i) the host protein hnRNP K is enriched in cytoplasmic membrane fractions following Sindbis virus infection, (ii) viral nonstructural proteins co-immunoprecipitate with hnRNP K, (iii) nsP2 and hnRNP K co-localize in the cytoplasm of Sindbis virus infected cells, (iv) Sindbis virus subgenomic mRNA, but not genomic RNA co-immunoprecipitates with hnRNP K, (v) viral RNA does not appear to be required for the interaction of hnRNP K with the nonstructural proteins. Potential functions of hnRNP K during virus replication are discussed.","is_dataset_classified":null,"base_score":4.454347296253507,"endowment":4.454347296253507,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17561226","pmcid":null,"openalex_id":"https://openalex.org/W1973392335","authors":[],"funders":[{"funder_name":"NCRR NIH HHS","grant_id":"5P41RR018942","title":null}],"total_grants":1,"fwci":1.5087,"citation_percentile":0.80520355,"influential_citations":0,"citation_trend":[{"year":2012,"count":8},{"year":2013,"count":10},{"year":2014,"count":5},{"year":2015,"count":4},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2018,"count":5},{"year":2019,"count":6},{"year":2020,"count":4},{"year":2021,"count":4},{"year":2022,"count":6},{"year":2023,"count":3},{"year":2024,"count":5},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"closed","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0042682207003480?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0042682207003480?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.virol.2007.05.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17561226","host_type":"repository"}],"fields_of_study":["Viral Infectious Diseases and Gene Expression in Insects","Insect Resistance and Genetics","Viral Infections and Immunology Research"],"mesh_terms":["Animals","Cell Membrane","Cysteine Endopeptidases","Cricetinae","HeLa Cells","Humans","RNA, Messenger","RNA, Viral","Sindbis Virus","Electrophoresis, Gel, Two-Dimensional","Genome, Viral","Viral Nonstructural Proteins","Heterogeneous-Nuclear Ribonucleoprotein K","Hela Cells"],"keywords":["Sindbis virus","Biology","Alphavirus","Subgenomic mRNA","Virology","RNA","Virus","Cytoplasm","Viral replication","Messenger RNA","Viral protein","Molecular biology","Gene","Cell biology","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T00:18:45.101052Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}