{"doi":"10.1016/j.virol.2007.04.010","title":"DNA/MVA HIV-1/AIDS vaccine elicits long-lived vaccinia virus-specific immunity and confers protection against a lethal monkeypox challenge","abstract":null,"journal":"Virology","year":2007,"id":594482,"datarank":0.6166310796259968,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":0.0,"self_endowment_contribution":0.6166310796259968,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":321485,"name":"Patricia L. Earl","orcid":"0009-0007-2610-1271","position":1,"is_corresponding":false},{"id":321486,"name":"Jeffrey L. Americo","orcid":"0009-0001-8648-6325","position":2,"is_corresponding":false},{"id":1333379,"name":"Sunita Sharma","orcid":"0000-0002-7125-0045","position":3,"is_corresponding":false},{"id":126151,"name":"Linda S. Wyatt","orcid":null,"position":4,"is_corresponding":false},{"id":1521860,"name":"Yvette Edghill-Spano","orcid":null,"position":5,"is_corresponding":false},{"id":1521861,"name":"Lakshmi S. Chennareddi","orcid":null,"position":6,"is_corresponding":false},{"id":1521862,"name":"Peter Silvera","orcid":null,"position":7,"is_corresponding":false},{"id":321487,"name":"Bernard Moss","orcid":"0000-0002-2154-8564","position":8,"is_corresponding":false},{"id":432141,"name":"Harriet L. Robinson","orcid":"0000-0001-6380-3458","position":9,"is_corresponding":false},{"id":253824,"name":"Rama Rao Amara","orcid":"0000-0002-6309-6797","position":10,"is_corresponding":false},{"id":1521859,"name":"Pragati Nigam","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"DNA/MVA HIV-1/AIDS vaccine elicits long-lived vaccinia virus-specific immunity and confers protection against a lethal monkeypox challenge","abstract":"Modified vaccinia Ankara (MVA) is being tested in humans as an alternative to the current smallpox vaccine Dryvax. Here, we compare the magnitude and longevity of protective immune responses elicited by a DNA/MVA HIV-1 vaccine with those elicited by Dryvax using a monkeypox virus/macaque model. The DNA/MVA vaccine elicited similar levels of vaccinia virus (VV)-specific antibody and 5-10-fold lower levels of VV-specific cellular responses than Dryvax. This MVA-elicited cellular and humoral immunity was long-lived. A subset of the DNA/MVA- and Dryvax-vaccinated macaques were subjected to a lethal monkeypox virus challenge at 3 years after vaccination. All of the vaccinated monkeys survived, whereas the unvaccinated controls succumbed to monkeypox. The viral control correlated with early postchallenge levels of monkeypox-specific neutralizing antibody but not with VV-specific cellular immune response. Thus, our results demonstrate the elicitation of long lasting protective immunity for a lethal monkeypox challenge by a DNA/MVA HIV-1 vaccine.","is_dataset_classified":null,"base_score":4.110873864173311,"endowment":4.110873864173311,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17507071","pmcid":"PMC2072046","openalex_id":"https://openalex.org/W1970263819","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI057029","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R21 AI053488","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"P51 RR00165","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R21 AI53488","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI57029","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"P01 AI49364","title":null},{"funder_name":"NCRR NIH HHS","grant_id":"P51 RR000165","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"P01 AI049364","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R21AI053488-01","title":"MVA/HIV-48: Potential Dual Vaccine for HIV and Smallpox"},{"funder_name":"National Institutes of Health","grant_id":"5P01AI049364-02","title":"Core--Macaque studies"},{"funder_name":"National Institutes of Health","grant_id":"5P51RR000165-35","title":"YERKES REGIONAL PRIMATE RESEARCH CENTER"},{"funder_name":"National Institutes of Health","grant_id":"5R01AI057029-02","title":"Poxvirus Immunity and DNA/MVA HIV Vaccines"},{"funder_name":"Intramural NIH HHS","grant_id":"","title":null}],"total_grants":13,"fwci":1.4363,"citation_percentile":0.77556473,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":2},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2019,"count":1},{"year":2021,"count":1},{"year":2022,"count":9},{"year":2023,"count":8},{"year":2024,"count":2},{"year":2025,"count":6},{"year":2026,"count":3}],"oa_status":"green","license":"Elsevier Non-Commercial","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2072046","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2072046","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0042682207002632?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0042682207002632?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.virol.2007.04.010","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17507071","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC2072046","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC2072046?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1016/j.virol.2007.04.010","host_type":""},{"url":"https://dx.doi.org/10.1016/j.virol.2007.04.010","host_type":""}],"fields_of_study":["Poxvirus research and outbreaks","Immunotherapy and Immune Responses","Herpesvirus Infections and Treatments","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Macaca","Monkeypox virus","Vaccinia virus","CD4-Positive T-Lymphocytes","AIDS Vaccines","CD8-Positive T-Lymphocytes","Primate Diseases","Mpox, Monkeypox","Mpox (monkeypox)"],"keywords":["Monkeypox","Vaccinia","Modified vaccinia Ankara","Virology","Biology","Poxviridae","Orthopoxvirus","Smallpox vaccine","Immunity","Virus","Vaccination","Cowpox","DNA vaccination","Immune system","Immunology","Immunization","Genetics","AIDS Vaccines","CD4-Positive T-Lymphocytes","Primate Diseases","HIV","CD8 T cells","Vaccinia virus","CD8-Positive T-Lymphocytes","Article","Mpox, Monkeypox","Rhesus macaque","Animals","Macaca","Monkeypox virus","DNA/MVA vaccine","Modified vaccinia virus Ankara","Smallpox"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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