{"doi":"10.1016/j.virol.2004.03.007","title":"Multiple signal transducers and activators of transcription are induced by EBV LMP-1","abstract":null,"journal":"Virology","year":2004,"id":662128,"datarank":0.5570358100056463,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.0,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":819191,"name":"Ke Hong","orcid":"0000-0003-3300-6970","position":1,"is_corresponding":false},{"id":106134,"name":"Jun Zhang","orcid":"0000-0002-1289-0624","position":2,"is_corresponding":false},{"id":1728538,"name":"Joseph S Pagano","orcid":null,"position":3,"is_corresponding":false},{"id":478961,"name":"Luwen Zhang","orcid":"0000-0002-8876-3947","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Multiple signal transducers and activators of transcription are induced by EBV LMP-1","abstract":"Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) is required for EBV immortalization of primary B cells in vitro. Signal transducers and activators of transcription (STATs) play a pivotal role in the initiation and maintenance of certain cancers. STAT proteins, especially STAT-1, -3, and -5, are persistently tyrosine phosphorylated or activated in many cancers. We show here that EBV-infected type III latency cells, in which the EBV oncoprotein, LMP-1 is expressed, express high levels of four STATs (STAT-1, -2, -3, and -5A) and that LMP-1 is responsible for the induction of three (STAT-1, -2, and -3). In addition, the C-terminal activator region 1 (CTAR-1) and CTAR-2 of LMP-1 cooperatively induced the expression of STAT-1. The cooperativity was evident when CTAR-1 and CTAR-2 were present in cis, but not in trans. Furthermore, NF-kappaB is an essential factor involved in the induction of STAT-1. Most of the induced STATs were not phosphorylated at the critical tyrosine residue activated by many cytokines. However, the induced STATs, at least STAT-1, were functional because it could be activated by interferon (IFN) and could upregulate an IFN-inducible gene. Finally, expression of STAT-1, but not STAT-2 and -3, is associated with EBV transformation. The association of the expression of STAT-1, -2, -3, and -5A with EBV type III latency and the expression of STAT-1 in the EBV transformation process may be part of the viral programming that regulates viral latency and cellular transformation.","is_dataset_classified":null,"base_score":3.713572066704308,"endowment":3.713572066704308,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15165826","pmcid":null,"openalex_id":"https://openalex.org/W2055426144","authors":[],"funders":[{"funder_name":"NCRR NIH HHS","grant_id":"RR15635","title":null},{"funder_name":"NCI NIH HHS","grant_id":"CA 19014","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"AI 42372-01","title":null}],"total_grants":3,"fwci":1.3154,"citation_percentile":0.79510983,"influential_citations":6,"citation_trend":[{"year":2013,"count":3},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2019,"count":4},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2024,"count":1}],"oa_status":"bronze","license":"http://www.elsevier.com/open-access/userlicense/1.0/","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0042682204001710/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0042682204001710/pdf","host_type":"BRONZE"},{"url":"https://www.sciencedirect.com/science/article/pii/S0042682204001710/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0042682204001710?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0042682204001710?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.virol.2004.03.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15165826","host_type":"repository"},{"url":"https://digitalcommons.unl.edu/virologypub/24","host_type":"repository"}],"fields_of_study":["Viral-associated cancers and disorders","T-cell and Retrovirus Studies","Immune Cell Function and Interaction","Medicine","Biology"],"mesh_terms":["B-Lymphocytes","Cell Line","Cell Line, Transformed","DNA-Binding Proteins","Herpesvirus 4, Human","Gene Expression Regulation","Humans","Phosphorylation","RNA","Viral Matrix Proteins","Trans-Activators","NF-kappa B","Virus Latency","Cell Line, Tumor","STAT1 Transcription Factor","STAT2 Transcription Factor","STAT3 Transcription Factor"],"keywords":["stat","STAT4","Biology","STAT protein","STAT1","JAK-STAT signaling pathway","STAT6","STAT2","Interferon","Transcription factor","Cell biology","Tyrosine phosphorylation","Protein tyrosine phosphatase","Phosphorylation","Cancer research","Virology","STAT3","Gene","Receptor tyrosine kinase","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T12:48:42.713596Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}