{"doi":"10.1016/j.vetimm.2005.02.011","title":"Differences in the immunopathogenesis of infectious bursal disease virus (IBDV) following in ovo and post-hatch vaccination of chickens","abstract":null,"journal":"Veterinary Immunology and Immunopathology","year":2005,"id":685992,"datarank":0.5289540786924243,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"self_citation_contribution":0.5289540786924243,"citation_network_contribution":0.0,"self_endowment_contribution":0.5289540786924243,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1792248,"name":"Christine Haase","orcid":null,"position":1,"is_corresponding":false},{"id":1274045,"name":"Silke Rautenschlein","orcid":"0000-0002-8177-3755","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Differences in the immunopathogenesis of infectious bursal disease virus (IBDV) following in ovo and post-hatch vaccination of chickens","abstract":"Not much is known about IBDV-pathogenesis and immune mechanisms following in ovo vaccination. In this study, we compared the immunopathogenesis of an intermediate IBDV-vaccine in post-hatch- and in ovo-inoculated chickens. In ovo-vaccinated birds recovered significantly faster from lesions of the bursa of Fabricius than post-hatch vaccinated (P<0.05). A significant accumulation of intrabursal CD8(+) T cells was observed in post-hatch but not in in ovo-vaccinated chickens (P<0.05). The innate immunity was comparable between in ovo- and post-hatch-vaccinated groups as indicated by comparable intrabursal macrophage accumulation and intrabursal IBDV-clearance. Overall, our observations indicate that IBDV in ovo vaccination may be advantageous over post-hatch. In ovo-vaccinated birds recover faster from bursa lesions and exhibit similar protection against challenge in comparison to post-hatch vaccinated.","is_dataset_classified":null,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15911001","pmcid":null,"openalex_id":"https://openalex.org/W2090416652","authors":[],"funders":[],"total_grants":0,"fwci":0.9546,"citation_percentile":0.76304702,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":3},{"year":2014,"count":1},{"year":2016,"count":3},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":5},{"year":2021,"count":2},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0165242705000620?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0165242705000620?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.vetimm.2005.02.011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15911001","host_type":"repository"}],"fields_of_study":["Virology and Viral Diseases","Vector-Borne Animal Diseases","Trypanosoma species research and implications","Animals","Antibodies, Viral","Antigens, Viral","Birnaviridae Infections","Bursa of Fabricius","CD4-Positive T-Lymphocytes","CD8-Positive T-Lymphocytes","Chick Embryo","Chickens","Immunization Schedule","Infectious bursal disease virus","Poultry Diseases","Specific Pathogen-Free Organisms","Viral Vaccines"],"mesh_terms":["Animals","Antibodies, Viral","Antigens, Viral","Bursa of Fabricius","Chick Embryo","Chickens","Immunization Schedule","Infectious bursal disease virus","Poultry Diseases","Specific Pathogen-Free Organisms","Viral Vaccines","CD4-Positive T-Lymphocytes","Birnaviridae Infections","CD8-Positive T-Lymphocytes"],"keywords":["Infectious bursal disease","In ovo","Biology","Virology","Virus","Vaccination","Disease","Immunology","Pathology","Embryo","Medicine","Virulence","Genetics","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T18:16:16.115953Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}