{"doi":"10.1016/j.vesic.2025.100084","title":"Using common features of viruses and EVs for a novel EV-based lateral flow test for HIV","abstract":"The similarities between extracellular vesicles (EVs) and viruses make them challenging to distinguish and separate into unique populations. A novel lateral flow test has been developed by utilizing these shared properties to improve at-home testing for HIV. By targeting EVs released from HIV infected cells (HIV-EVs) and HIV virus particles for immunocapture, which share common transmembrane proteins like tetraspanins, HIV proteins can be concentrated from blood samples in a lateral flow device. Others have described immunocapture of EVs by lateral flow; here we describe capture and lysis for downstream detection of specific HIV cargo for a sensitive antigen-only HIV test. We found that HIV antigens p24 and Nef are detected early in infection and may significantly improve the sensitivity of an at-home test format by utilizing EVs as a novel reservoir of HIV antigens.","journal":"Extracellular Vesicle","year":2025,"id":568202,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1102618,"name":"Kaitlyn King","orcid":null,"position":1,"is_corresponding":false},{"id":1473017,"name":"Gary Baisa","orcid":null,"position":2,"is_corresponding":false},{"id":433168,"name":"John Hural","orcid":null,"position":3,"is_corresponding":false},{"id":1472605,"name":"Kimberly Luke","orcid":"0000-0002-2145-2474","position":4,"is_corresponding":false},{"id":1473016,"name":"Casey Scott-Weathers","orcid":null,"position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T02:56:52.212268Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}