{"doi":"10.1016/j.vaccine.2020.04.034","title":"An effective CTL peptide vaccine for Ebola Zaire Based on Survivors’ CD8+ targeting of a particular nucleocapsid protein epitope with potential implications for COVID-19 vaccine design","abstract":"The 2013-2016 West Africa EBOV epidemic was the biggest EBOV outbreak to date. An analysis of virus-specific CD8+ T-cell immunity in 30 survivors showed that 26 of those individuals had a CD8+ response to at least one EBOV protein. The dominant response (25/26 subjects) was specific to the EBOV nucleocapsid protein (NP). It has been suggested that epitopes on the EBOV NP could form an important part of an effective T-cell vaccine for Ebola Zaire. We show that a 9-amino-acid peptide NP44-52 (YQVNNLEEI) located in a conserved region of EBOV NP provides protection against morbidity and mortality after mouse adapted EBOV challenge. A single vaccination in a C57BL/6 mouse using an adjuvanted microsphere peptide vaccine formulation containing NP44-52 is enough to confer immunity in mice. Our work suggests that a peptide vaccine based on CD8+ T-cell immunity in EBOV survivors is conceptually sound and feasible. Nucleocapsid proteins within SARS-CoV-2 contain multiple Class I epitopes with predicted HLA restrictions consistent with broad population coverage. A similar approach to a CTL vaccine design may be possible for that virus.","journal":"Vaccine","year":2020,"id":59792,"datarank":0.6284482113039639,"base_score":4.189654742026425,"endowment":4.189654742026425,"self_citation_contribution":0.6284482113039639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6284482113039639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":314953,"name":"Scott Burkholz","orcid":"0000-0003-0804-1985","position":1,"is_corresponding":false},{"id":55666,"name":"John Sidney","orcid":"0000-0002-0987-405X","position":2,"is_corresponding":false},{"id":55670,"name":"Alessandro Sette","orcid":"0000-0001-7013-2250","position":3,"is_corresponding":false},{"id":314954,"name":"Paul E. Harris","orcid":"0000-0003-4806-8242","position":4,"is_corresponding":false},{"id":316132,"name":"Shane Massey","orcid":null,"position":5,"is_corresponding":false},{"id":218440,"name":"Trevor Brasel","orcid":null,"position":6,"is_corresponding":false},{"id":314955,"name":"Edécio Cunha‐Neto","orcid":"0000-0002-3699-3345","position":7,"is_corresponding":false},{"id":314956,"name":"Daniela Santoro Rosa","orcid":"0000-0003-4536-891X","position":8,"is_corresponding":false},{"id":314957,"name":"William Chong Hang Chao","orcid":"0000-0003-4951-796X","position":9,"is_corresponding":false},{"id":314958,"name":"Richard T. Carback","orcid":"0000-0002-2330-6323","position":10,"is_corresponding":false},{"id":314959,"name":"Tom Hodge","orcid":"0009-0008-1415-5990","position":11,"is_corresponding":false},{"id":49239,"name":"L. Wang","orcid":"0009-0007-8928-0326","position":12,"is_corresponding":false},{"id":316133,"name":"Serban Ciotlos","orcid":null,"position":13,"is_corresponding":false},{"id":314960,"name":"Peter Lloyd","orcid":"0009-0007-2337-7459","position":14,"is_corresponding":false},{"id":314961,"name":"Reid Rubsamen","orcid":"0000-0003-4856-2371","position":15,"is_corresponding":false},{"id":314952,"name":"C.v. Herst","orcid":"0000-0002-0686-1181","position":0,"is_corresponding":true}],"reference_count":79,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:08:26.834549Z","pmid":"32418793","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}